(R)-lipoic Acid

(R)-lipoic Acid Uses, Dosage, Side Effects, Food Interaction and all others data.

A vitamin-like antioxidant.

(R)-lipoic Acid (or α-lipoic acid) is able to pass the blood-brain barrier and is putatively used for detoxification of mercury attached to the brain cells. It can mobilise bound mercury into the blood stream as it is a mercaptan (sulfur compound which readily binds to the mercury). In the blood stream, another chelator such as dimercaptosuccinic acid (DMSA) or methylsulfonylmethane (MSM) is used to transfer mercury safely into the urine for excretion. Neither DMSA nor MSM can cross the blood-brain barrier, which is why both lipoic acid and DMSA are used. It is hypothesized that this treatment-along with carnitine, dimethylglycine (DMG), Vitamin B6, folic acid, and magnesium—could be used to treat autism and amalgam poisoning. In this hypothesis, the reason why autism is difficult to treat is that mercury is attached to the brain cells and most medicines and vitamin supplements do not penetrate the blood-brain barrier. However, α-lipoic acid and perhaps vitamin B12 could making it possible for other chelators to remove mercury safely out of the body and could perhaps one day be used as a treatment for autism. Because lipoic acid is related to cellular uptake of glucose and it is both soluble in water and fat, it is being used for treatment in diabetes. It may be helpful for people with Alzheimer's disease or Parkinson's disease.

Trade Name (R)-lipoic Acid
Generic Lipoic acid
Lipoic acid Other Names (R)-lipoic acid, Alpha lipoic acid, alpha-Lipoic acid, alpha-Liponsäure, D-thioctic acid, Lipoic acid, R-alpha-lipoic acid, Thioctic acid, Thioctic acid D-form
Type
Formula C8H14O2S2
Weight Average: 206.326
Monoisotopic: 206.043521072
Groups Approved, Investigational, Nutraceutical
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
(R)-lipoic Acid
(R)-lipoic Acid

Uses

For nutritional supplementation, also for treating dietary shortage or imbalance.

(R)-lipoic Acid is also used to associated treatment for these conditions: Diabetic Neuropathies, Type 2 Diabetes Mellitus, Dietary and Nutritional Therapies, Nutritional supplementation

How (R)-lipoic Acid works

Lipoic Acid is generally involved in oxidative decarboxylations of keto acids and is presented as a growth factor for some organisms. (R)-lipoic Acid exists as two enantiomers, the R-enantiomer and the S-enantiomer. Normally only the R-enantiomer of an amino acid is biologically active, but for lipoic acid the S-enantiomer assists in the reduction of the R-enantiomer when a racemic mixture is given. Some recent studies have suggested that the S-enantiomer in fact has an inhibiting effect on the R-enantiomer, reducing its biological activity substantially and actually adding to oxidative stress rather than reducing it. Furthermore, the S-enantiomer has been found to reduce the expression of GLUT-4s in cells, responsible for glucose uptake, and hence reduce insulin sensitivity.

Food Interaction

No interactions found.

Innovators Monograph

You find simplified version here (R)-lipoic Acid

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*** Taking medicines without doctor's advice can cause long-term problems.
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