L-Isoleucine

L-Isoleucine Uses, Dosage, Side Effects, Food Interaction and all others data.

An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of leucine. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.

They provide ingredients for the manufacturing of other essential biochemical components in the body, some of which are utilized for the production of energy, stimulants to the upper brain and helping you to be more alert.

Trade Name L-Isoleucine
Generic Isoleucine
Isoleucine Other Names Isoleucina, Isoleucine, Isoleucinum, L-Isoleucine
Type
Formula C6H13NO2
Weight Average: 131.1729
Monoisotopic: 131.094628665
Groups Investigational, Nutraceutical
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
L-Isoleucine
L-Isoleucine

Uses

L-Isoleucine is an amino acid commonly found as a component of total parenteral nutrition.

The branched-chain amino acids may have antihepatic encephalopathy activity in some. They may also have anticatabolic and antitardive dyskinesia activity.

L-Isoleucine is also used to associated treatment for these conditions: Amino acid supplementation

How L-Isoleucine works

(Applies to Valine, Leucine and L-Isoleucine)
This group of essential amino acids are identified as the branched-chain amino acids, BCAAs. Because this arrangement of carbon atoms cannot be made by humans, these amino acids are an essential element in the diet. The catabolism of all three compounds initiates in muscle and yields NADH and FADH2 which can be utilized for ATP generation. The catabolism of all three of these amino acids uses the same enzymes in the first two steps. The first step in each case is a transamination using a single BCAA aminotransferase, with a-ketoglutarate as amine acceptor. As a result, three different a-keto acids are produced and are oxidized using a common branched-chain a-keto acid dehydrogenase, yielding the three different CoA derivatives. Subsequently the metabolic pathways diverge, producing many intermediates.
The principal product from valine is propionylCoA, the glucogenic precursor of succinyl-CoA. L-Isoleucine catabolism terminates with production of acetylCoA and propionylCoA; thus isoleucine is both glucogenic and ketogenic. Leucine gives rise to acetylCoA and acetoacetylCoA, and is thus classified as strictly ketogenic.
There are a number of genetic diseases associated with faulty catabolism of the BCAAs. The most common defect is in the branched-chain a-keto acid dehydrogenase. Since there is only one dehydrogenase enzyme for all three amino acids, all three a-keto acids accumulate and are excreted in the urine. The disease is known as Maple syrup urine disease because of the characteristic odor of the urine in afflicted individuals. Mental retardation in these cases is extensive. Unfortunately, since these are essential amino acids, they cannot be heavily restricted in the diet; ultimately, the life of afflicted individuals is short and development is abnormal The main neurological problems are due to poor formation of myelin in the CNS.

Toxicity

Symptoms of hypoglycemia, increased mortality in ALS patients taking large doses of BCAAs

Elimination Route

Absorbed from the small intestine by a sodium-dependent active-transport process

Innovators Monograph

You find simplified version here L-Isoleucine

http://classyfire.wishartlab.com/tax_nodes/C0000000
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http://classyfire.wishartlab.com/tax_nodes/C0004176
http://classyfire.wishartlab.com/tax_nodes/C0001137
http://classyfire.wishartlab.com/tax_nodes/C0001205
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0000469
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17191
http://www.genome.jp/dbget-bin/www_bget?cpd:C00407
http://www.lipidmaps.org/data/LMSDRecord.php?LMID=LMFA01100047
http://www.hmdb.ca/metabolites/HMDB0000172
http://www.genome.jp/dbget-bin/www_bget?drug:D00065
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http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18140
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6033
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=58045
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https://zinc.docking.org/substances/ZINC000003581355
http://www.pharmgkb.org/drug/PA164750430
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http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/bra_0042.shtml
https://en.wikipedia.org/wiki/Isoleucine
*** Taking medicines without doctor's advice can cause long-term problems.
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