Pentagastrin

Pentagastrin Uses, Dosage, Side Effects, Food Interaction and all others data.

A synthetic pentapeptide that mimics the actions of endogenous gastrin when given parenterally. It works by stimulating the secretion of gastric acid, pepsin, and intrinsic factor. It has also been used as a diagnostic aid.

Pentagastrin is indicated as a diagnostic aid for evaluation of gastric acid secretory function. It is effective in testing for anacidity (achlorhydria) in patients with suspected pernicious anemia, atrophic gastritis, or gastric carcinoma. It is also effective in determining the reduction in acid output after operations for peptic ulcer, such as vagotomy or gastric resection.

Pentagastrin
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Pentagastrin
Availability	Discontinued
Generic	Pentagastrin
Pentagastrin Other Names	Pentagastrin
Type
Formula	C₃₇H₄₉N₇O₉S
Weight	Average: 767.9 Monoisotopic: 767.33124736
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Pentagastrin is a gastrin-like molecule used as a diagnostic aid for the evaluation of gastric acid secretory function, gastric hypersecretion, and Zollinger-Ellison tumors.

Used as a diagnostic aid for evaluation of gastric acid secretory function

Pentagastrin is also used to associated treatment for these conditions: C-cell hyperplasia, Medullary Thyroid Cancer (MTC)

How Pentagastrin works

The exact mechanism by which pentagastrin stimulates gastric acid, pepsin, and intrinsic factor secretion is unknown; however, since pentagastrin is an analogue of natural gastrin, it is believed that it excites the oxyntic cells of the stomach to secrete to their maximum capacity. Pentagastrin stimulates pancreatic secretion, especially when administered in large intramuscular doses. Pentagastrin also increases gastrointestinal motility by a direct effect on the intestinal smooth muscle. However, it delays gastric emptying time probably by stimulation of terminal antral contractions, which enhance retropulsion.