Cevimelina

Cevimelina Uses, Dosage, Side Effects, Food Interaction and all others data.

Cevimelina is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome.

Cevimelina is a cholinergic agonist which binds to muscarinic receptors. Muscarinic agonists in sufficient dosage can increase secretion of exocrine glands, such as salivary and sweat glands and increase tone of the smooth muscle in the gastrointestinal and urinary tracts.

Trade Name Cevimelina
Availability Prescription only
Generic Cevimeline
Cevimeline Other Names Cevimelina, Cévimèline, Cevimeline, Cevimelinum
Related Drugs Evoxac
Type
Formula C10H17NOS
Weight Average: 199.313
Monoisotopic: 199.103084861
Protein binding

< 20%

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Cevimelina
Cevimelina

Uses

Cevimelina is a muscarinic agonist with parasympathomimetic activities that is used for the symptomatic treatment of dry mouth in patients with Sjögren's Syndrome.

For the treatment of symptoms of dry mouth in patients with Sjögren's Syndrome.

Cevimelina is also used to associated treatment for these conditions: Dry Mouth

How Cevimelina works

Muscarinic agonists such as cevimeline bind and activate the muscarinic M1 and M3 receptors. The M1 receptors are common in secretory glands (exocrine glands such as salivary and sweat glands), and their activation results in an increase in secretion from the secretory glands. The M3 receptors are found on smooth muscles and in many glands which help to stimulate secretion in salivary glands, and their activation generally results in smooth muscle contraction and increased glandular secretions. Therefore, as saliva excretion is increased, the symptoms of dry mouth are relieved.

Food Interaction

No interactions found.

Volume of Distribution

  • 6 L/kg

Elimination Route

Rapidly absorbed with peak concentration after 1.5 to 2 hours

Half Life

5 ± 1 hours

Elimination Route

After 24 hours, 84% of a 30 mg dose of cevimeline was excreted in urine.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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