Paromomycin

Paromomycin Uses, Dosage, Side Effects, Food Interaction and all others data.

An oligosaccharide antibiotic produced by various streptomyces. [PubChem]

Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin.

Paromomycin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Paromomycin
Availability	Prescription only
Generic	Paromomycin
Paromomycin Other Names	Aminosidin, Aminosidine, Catenulin, Crestomycin, Estomycin, Hydroxymycin, Monomycin A, Neomycin E, Paromomicina, Paromomycin, Paromomycin I, Paromomycine, Paromomycinum, Paucimycin, Paucimycinum, Zygomycin A1
Related Drugs	doxycycline, metronidazole, Flagyl, albendazole, neomycin, Vibramycin, tinidazole, nitazoxanide, praziquantel, niclosamide
Weight	250mg
Type	Oral capsule
Formula	C₂₃H₄₅N₅O₁₄
Weight	Average: 615.6285 Monoisotopic: 615.296301173
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Paromomycin is an aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma.

For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.

Paromomycin is also used to associated treatment for these conditions: Dientamoeba fragilis infection, Hepatic coma, Acute Intestinal amebiasis, Chronic Intestinal amebiasis

How Paromomycin works

Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.