Crestomycin

Crestomycin Uses, Dosage, Side Effects, Food Interaction and all others data.

An oligosaccharide antibiotic produced by various streptomyces. [PubChem]

Crestomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin.

Trade Name Crestomycin
Availability Prescription only
Generic Paromomycin
Paromomycin Other Names Aminosidin, Aminosidine, Catenulin, Crestomycin, Estomycin, Hydroxymycin, Monomycin A, Neomycin E, Paromomicina, Paromomycin, Paromomycin I, Paromomycine, Paromomycinum, Paucimycin, Paucimycinum, Zygomycin A1
Related Drugs doxycycline, metronidazole, Flagyl, albendazole, neomycin, Vibramycin, tinidazole, nitazoxanide, praziquantel, niclosamide
Type
Formula C23H45N5O14
Weight Average: 615.6285
Monoisotopic: 615.296301173
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Crestomycin
Crestomycin

Uses

Crestomycin is an aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma.

For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.

Crestomycin is also used to associated treatment for these conditions: Dientamoeba fragilis infection, Hepatic coma, Acute Intestinal amebiasis, Chronic Intestinal amebiasis

How Crestomycin works

Crestomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.

Food Interaction

  • Take with food.

Crestomycin Disease Interaction

Major: intestinal obstruction, colitis, GI inflammation

Elimination Route

Poorly absorbed after oral administration, with almost 100% of the drug recoverable in the stool.

Innovators Monograph

You find simplified version here Crestomycin

*** Taking medicines without doctor's advice can cause long-term problems.
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