Натрия тиосульфат Uses, Dosage, Side Effects and more
Sodium thiosulfate acts as an antidote in the treatment of cyanide poisoning. It acts as a sulphur-donating substrate for the enzyme rhodanese, thus speeding up the conversion of cyanide to thiocyanide, which is relatively non toxic. It is often used in combination with sodium nitrite but may be used alone in less severe poisoning.
| Attribute | Details |
|---|---|
| Trade Name | Натрия тиосульфат |
| Generic | Sodium Thiosulfate |
| Type | |
| Therapeutic Class | Antidote preparations |
| Manufacturer | |
| Available Country | Russia |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Cyanide poisoning
Dosage
Adult: To be given after 300 mg of sodium nitrite has been admin over 5-20 min: 12.5 g of sodium thiosulfate (50 ml of a 25% solution or 25 ml of a 50% solution) given over 10 min. Methaemoglobin concentration should not exceed 30-40%. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may be repeated after 30 min at half the initial doses.
Child: To be given after 4-10 mg/kg of sodium nitrite (max: 300 mg) has been admin: 400 mg/kg of sodium thiosulfate, as a 25 or 50% solution (max: 12.5 g). Methaemoglobin concentration should not exceed 30-40%. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may be repeated after 30 min at half the initial doses.
Side Effects
Osmotic disturbances. Oral: catharsis (at high doses).
Precaution
May irritate eyes, skin and respiratory tract.
Interaction
Decreases toxicity of cisplatin through rapid chemical inactivation of its platinum component.
Pregnancy & Breastfeeding use
Pregnancy Category- C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Contraindication
Oedematous sodium-retaining conditions.
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FAQ
What is Натрия тиосульфат used for?
Натрия тиосульфат used as a medication to treat cyanide poisoning, pityriasis versicolor, and to decrease side effects from cisplatin. For cyanide poisoning it is often used after the medication sodium nitrite and typically only recommended for severe cases.
How safe is Натрия тиосульфат?
Ingestion of large amounts may cause gastrointestinal irritation.May cause respiratory tract irritation. Low hazard for usual industrial handling.
How does Натрия тиосульфат work?
Натрия тиосульфат works by helping cells in the body convert cyanide to a form that can be removed from the body through urination.
What are the common side effects of Натрия тиосульфат?
Common side effects of Натрия тиосульфат are include:
- Agitation.
- hallucinations (seeing, hearing, or feeling things that are not there)
- mental changes.
- muscle cramps.
- nausea and vomiting.
- pain in the joints.
- ringing in the ears.
Is Натрия тиосульфат safe during pregnancy?
If Натрия тиосульфат is required in the management of cyanide poisoning during pregnancy, treatment should not be withheld on account of pregnancy.
Is Натрия тиосульфат safe during breastfeeding?
Breastfeeding is not recommended.There is no information regarding this drug on the presence in human milk, the effects on a breastfed infant, or effects on milk production.
What happens if I ingest Натрия тиосульфат?
light-headed feeling, like you might pass out, shortness of breath, tiredness; fast or irregular heart rate, pounding heartbeats or fluttering in your chest.
What does Натрия тиосульфат do to the body?
Натрия тиосульфат works by helping cells in the body convert cyanide to a form that can be removed from the body through urination.
How quickly does Натрия тиосульфат work?
Symptomatic relief and clinical improvement may occur within 2 weeks.
Is Натрия тиосульфат good for skin?
Натрия тиосульфат is used to treat a fungal infection of the skin called tinea versicolor.
Is Натрия тиосульфат bad for my skin?
Do not put on irritated skin. If you use Натрия тиосульфат and salicylic acid too often, your skin problem may become worse. Talk with your doctor before you use other drugs or products on your skin.
Does Натрия тиосульфат lower blood pressure?
Натрия тиосульфат can causes Low blood pressure also with other side effects.
When do I administer Натрия тиосульфат?
Натрия тиосульфат may be administered soon after prior treatment with a fast-acting cyanide antidote such as Натрия тиосульфат. Blood pressure must be monitored during infusion in both adults and children. The rate of infusion should be decreased if significant hypotension is noted.
Is Натрия тиосульфат light sensitive?
None under normal processing. Chemical Stable under normal conditions. Light sensitive.
Is Натрия тиосульфат a salicylic acid?
Натрия тиосульфат is an antifungal medicine that fights infections caused by fungus. salicylic acid helps your skin absorb the sodium thiosulfate.
Is Натрия тиосульфат a chemical antidote?
Натрия тиосульфат can be used for treatment of acute cyanide poisoning in combination with sodium nitrite.
How long is Натрия тиосульфат good for?
At the time of the case report, 18 months had elapsed since the infusions were discontinued, and the patient remained free of skin lesions. Based on the lack of recurrence with extended treatment, the authors suggested that the optimal duration of Натрия тиосульфат therapy is several months.
Is Натрия тиосульфат harmful to fish?
Excess Натрия тиосульфат up to 100 parts per million will not harm fish.
How quickly does Натрия тиосульфат work?
Symptomatic relief and clinical improvement may occur within 2 weeks.
Does Натрия тиосульфат remove oxygen?
Натрия тиосульфат acts as an oxygen scavenger. Oxygen scavengers are reducing agents in that they remove dissolved oxygen from water by reducing molecular oxygen to compounds in which oxygen appears in the lower.
Can I overdose Натрия тиосульфат?
Натрия тиосульфат is used to treat cyanide poisoning. If a poisoning or overdose occurs, get emergency help. Do not treat a poisoning or overdose yourself.
Is Натрия тиосульфат toxic?
btrand is an agent with a low order of toxicity.
Who should not take Натрия тиосульфат?
Do not take this medication if you are allergic to Натрия тиосульфат or any ingredients contained in this drug.
