Натрия тиосульфат пентагидрат Uses, Dosage, Side Effects and more
Sodium thiosulfate acts as an antidote in the treatment of cyanide poisoning. It acts as a sulphur-donating substrate for the enzyme rhodanese, thus speeding up the conversion of cyanide to thiocyanide, which is relatively non toxic. It is often used in combination with sodium nitrite but may be used alone in less severe poisoning.
| Attribute | Details |
|---|---|
| Trade Name | Натрия тиосульфат пентагидрат |
| Generic | Sodium Thiosulfate |
| Type | |
| Therapeutic Class | Antidote preparations |
| Manufacturer | |
| Available Country | Russia |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Cyanide poisoning
Dosage
Adult: To be given after 300 mg of sodium nitrite has been admin over 5-20 min: 12.5 g of sodium thiosulfate (50 ml of a 25% solution or 25 ml of a 50% solution) given over 10 min. Methaemoglobin concentration should not exceed 30-40%. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may be repeated after 30 min at half the initial doses.
Child: To be given after 4-10 mg/kg of sodium nitrite (max: 300 mg) has been admin: 400 mg/kg of sodium thiosulfate, as a 25 or 50% solution (max: 12.5 g). Methaemoglobin concentration should not exceed 30-40%. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may be repeated after 30 min at half the initial doses.
Side Effects
Osmotic disturbances. Oral: catharsis (at high doses).
Precaution
May irritate eyes, skin and respiratory tract.
Interaction
Decreases toxicity of cisplatin through rapid chemical inactivation of its platinum component.
Pregnancy & Breastfeeding use
Pregnancy Category- C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Contraindication
Oedematous sodium-retaining conditions.
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FAQ
What is Натрия тиосульфат пентагидрат used for?
Натрия тиосульфат пентагидрат used as a medication to treat cyanide poisoning, pityriasis versicolor, and to decrease side effects from cisplatin. For cyanide poisoning it is often used after the medication sodium nitrite and typically only recommended for severe cases.
How safe is Натрия тиосульфат пентагидрат?
Ingestion of large amounts may cause gastrointestinal irritation.May cause respiratory tract irritation. Low hazard for usual industrial handling.
How does Натрия тиосульфат пентагидрат work?
Натрия тиосульфат пентагидрат works by helping cells in the body convert cyanide to a form that can be removed from the body through urination.
What are the common side effects of Натрия тиосульфат пентагидрат?
Common side effects of Натрия тиосульфат пентагидрат are include:
- Agitation.
- hallucinations (seeing, hearing, or feeling things that are not there)
- mental changes.
- muscle cramps.
- nausea and vomiting.
- pain in the joints.
- ringing in the ears.
Is Натрия тиосульфат пентагидрат safe during pregnancy?
If Натрия тиосульфат пентагидрат is required in the management of cyanide poisoning during pregnancy, treatment should not be withheld on account of pregnancy.
Is Натрия тиосульфат пентагидрат safe during breastfeeding?
Breastfeeding is not recommended.There is no information regarding this drug on the presence in human milk, the effects on a breastfed infant, or effects on milk production.
What happens if I ingest Натрия тиосульфат пентагидрат?
light-headed feeling, like you might pass out, shortness of breath, tiredness; fast or irregular heart rate, pounding heartbeats or fluttering in your chest.
What does Натрия тиосульфат пентагидрат do to the body?
Натрия тиосульфат пентагидрат works by helping cells in the body convert cyanide to a form that can be removed from the body through urination.
How quickly does Натрия тиосульфат пентагидрат work?
Symptomatic relief and clinical improvement may occur within 2 weeks.
Is Натрия тиосульфат пентагидрат good for skin?
Натрия тиосульфат пентагидрат is used to treat a fungal infection of the skin called tinea versicolor.
Is Натрия тиосульфат пентагидрат bad for my skin?
Do not put on irritated skin. If you use Натрия тиосульфат пентагидрат and salicylic acid too often, your skin problem may become worse. Talk with your doctor before you use other drugs or products on your skin.
Does Натрия тиосульфат пентагидрат lower blood pressure?
Натрия тиосульфат пентагидрат can causes Low blood pressure also with other side effects.
When do I administer Натрия тиосульфат пентагидрат?
Натрия тиосульфат пентагидрат may be administered soon after prior treatment with a fast-acting cyanide antidote such as Натрия тиосульфат пентагидрат. Blood pressure must be monitored during infusion in both adults and children. The rate of infusion should be decreased if significant hypotension is noted.
Is Натрия тиосульфат пентагидрат light sensitive?
None under normal processing. Chemical Stable under normal conditions. Light sensitive.
Is Натрия тиосульфат пентагидрат a salicylic acid?
Натрия тиосульфат пентагидрат is an antifungal medicine that fights infections caused by fungus. salicylic acid helps your skin absorb the sodium thiosulfate.
Is Натрия тиосульфат пентагидрат a chemical antidote?
Натрия тиосульфат пентагидрат can be used for treatment of acute cyanide poisoning in combination with sodium nitrite.
How long is Натрия тиосульфат пентагидрат good for?
At the time of the case report, 18 months had elapsed since the infusions were discontinued, and the patient remained free of skin lesions. Based on the lack of recurrence with extended treatment, the authors suggested that the optimal duration of Натрия тиосульфат пентагидрат therapy is several months.
Is Натрия тиосульфат пентагидрат harmful to fish?
Excess Натрия тиосульфат пентагидрат up to 100 parts per million will not harm fish.
How quickly does Натрия тиосульфат пентагидрат work?
Symptomatic relief and clinical improvement may occur within 2 weeks.
Does Натрия тиосульфат пентагидрат remove oxygen?
Натрия тиосульфат пентагидрат acts as an oxygen scavenger. Oxygen scavengers are reducing agents in that they remove dissolved oxygen from water by reducing molecular oxygen to compounds in which oxygen appears in the lower.
Can I overdose Натрия тиосульфат пентагидрат?
Натрия тиосульфат пентагидрат is used to treat cyanide poisoning. If a poisoning or overdose occurs, get emergency help. Do not treat a poisoning or overdose yourself.
Is Натрия тиосульфат пентагидрат toxic?
btrand is an agent with a low order of toxicity.
Who should not take Натрия тиосульфат пентагидрат?
Do not take this medication if you are allergic to Натрия тиосульфат пентагидрат or any ingredients contained in this drug.
