Mintezol

Mintezol Uses, Dosage, Side Effects, Food Interaction and all others data.

2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for strongyloidiasis. It has CNS side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)

Mintezol is a fungicide and parasiticide. Mintezol is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning. Mintezol is vermicidal and/or vermifugal against Ascaris lumbricoides ("common roundworm"), Strongyloides stercoralis (threadworm), Necator americanus, Ancylostoma duodenale (hookworm), Trichuris trichiura (whipworm), Ancylostoma braziliense (dog and cat hookworm), Toxocara canis, Toxocara cati (ascarids), and Enterobius vermicularis (pinworm). Mintezol also suppresses egg and/or larval production and may inhibit the subsequent development of those eggs or larvae which are passed in the feces.

Trade Name Mintezol
Availability Discontinued
Generic Thiabendazole
Thiabendazole Other Names TBDZ, Thiabendazole, Tiabendazol, Tiabendazole, Tiabendazolum
Related Drugs metronidazole, ivermectin, Flagyl, albendazole, mebendazole, nitazoxanide, piperazine, pyrantel, Albenza, Stromectol
Type Chewable tablets and suspension
Formula C10H7N3S
Weight Average: 201.248
Monoisotopic: 201.036067929
Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Mintezol
Mintezol

Uses

Mintezol is a benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections.

For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis.

How Mintezol works

The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase.

Toxicity

Overdosage may be associated with transient disturbances of vision and psychic alterations. The oral LD 50 is 3.6 g/kg, 3.1 g/kg and 3.8 g/kg in the mouse, rat, and rabbit respectively.

Elimination Route

Rapidly absorbed and peak plasma concentration is reached within 1 to 2 hours after the oral administration of a suspension. Some systemic absorption may occur from topical preparations applied to the skin.

Half Life

The half-life for thiabendazole in both normal and anephric patients is 1.2 hours (range 0.9 to 2 hours). The half-life for the 5-hydroxythiabendazole metabolite in both normal and anephric patients is 1.7 hours (range 1.4 to 2 hours).

Elimination Route

It is metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates.

Innovators Monograph

You find simplified version here Mintezol

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http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:45979
http://www.genome.jp/dbget-bin/www_bget?cpd:C07131
http://metacyc.org/META/new-image?type=COMPOUND&object=THIABENDAZOLE
http://www.hmdb.ca/metabolites/HMDB0014868
http://www.genome.jp/dbget-bin/www_bget?drug:D00372
http://www.genome.jp/dbget-bin/www_bget?cpd:C07131
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5430
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505131
https://www.chemspider.com/Chemical-Structure.5237.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121347
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=10450
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=45979
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL625
https://zinc.docking.org/substances/ZINC000000073711
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000664
http://www.pharmgkb.org/drug/PA164746466
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/TMG
http://www.rxlist.com/cgi/generic2/thiabendazole.htm
https://www.drugs.com/cdi/thiabendazole.html
https://en.wikipedia.org/wiki/Tiabendazole
*** Taking medicines without doctor's advice can cause long-term problems.
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