Mebendazole Uses, Dosage, Side Effects, Food Interaction and all others data.

Mebendazole is a synthetic derivative of benzimidazole with a potent anthelmintic activity against the most common nematodes and some cestodes. It is highly effective against ascariasis, enterobiasis, trichuriasis and hookworm infections. It is equally effective in single or in mixed infections. The effect of the drug is due to its ability to inhibit glucose uptake irreversibly but it does not affect blood glucose concentration in the host, even in high doses. Mebendazole does not necessitate any dosage calculation since the same dosage is used for children and adults. It can be taken at any time and no special procedures such as purging, use of laxatives and/or dietary changes are required. Parasite immobilization and death occur slowly and clearance from the gastro-intestinal tract may not be completed up to 3 days after administration.

Mebendazole is a (synthetic) broad-spectrum anthelmintic. The principal mode of action for Mebendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules.

Trade Name Mebendazole
Availability Prescription only
Generic Mebendazole
Mebendazole Other Names MBDZ, Mebendazol, Mébendazole, Mebendazole, Mebendazolum
Related Drugs metronidazole, Flagyl, albendazole, nitazoxanide, praziquantel, piperazine, pyrantel, Albenza, Alinia
Weight 100mg, 100mg/5ml, 500mg
Type Tablet, Oral Suspension, Oral Tablet, Chewable
Formula C16H13N3O3
Weight Average: 295.2927
Monoisotopic: 295.095691297
Protein binding


Groups Approved, Vet approved
Therapeutic Class Anti-helminthic
Manufacturer Benson Pharamceuticals,, Essential Drugs Company Ltd
Available Country Pakistan, Bangladesh, United States
Last Updated: September 19, 2023 at 7:00 am


Mebendazole is used for the treatment of pinworm (Enterobius vermicularis), round worm (Ascaris lumbricoides), hookworm (Ancylostoma duodenale and Necator americanus), whip worm (Trichuris trichiura), tape worm (Taenia solium and taenia saginata) and threadworm (Strongyloides stercoralis) in single or mixed infections

Mebendazole is also used to associated treatment for these conditions: Ancylostoma caninum infection, Ancylostoma duodenale infection, Ascaris lumbricoides infection, Capillariasis, Enterobius vermicularis infection, Filariasis, Giardiasis, Necatoriasis due to necator americanus, Strongyloides Stercoralis Infection, Taenia solium infection, Toxocariasis, Whipworm infection

How Mebendazole works

Mebendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.


Mebendazole dosage

Mebendazole 100 mg tablet and suspension: This have the same dosage schedule applies to adults & children.

Enterobiasis: A single tablet or 1 teaspoonful of the suspension.

Ascariasis, Ancylostomiasis, Trichuriasis: 2 tablets, one in the morning, the other in the afternoon for 3 consecutive days or 1 teaspoonful in the morning & 1 teaspoonful in the afternoon for 3 consecutive days

Taeniasis & strongyloidiasis:

  • Adults: 2 tablets twice daily for 3 consecutive days.
  • Children: 1 tablet twice daily or 1 teaspoonful twice daily for 3 consecutive days.

Mebendazole 500 mg tablet: One Mebendazole 500 mg tablet in a single intake regardless of body weight, for all nematode and some cestode infestations. The same dosage applies to adults and children age two years and above.

May be taken with or without food.

Side Effects

Mebendazole is well tolerated by adults and children. It has virtually no side effects. Transient abdominal pain and diarrhoea have been reported only rarely, in case of massive infestation and expulsion of worms.


Acute oral toxicity (LD50): 620 mg/kg [Mouse]. Symptoms of overdose include elevated liver enzymes, headaches, hair loss, low levels of white blood cells (neutropenia), fever, and itching.


Hepatic impairment. Children. Pregnancy and lactation.


Concomitant treatment with cimetidine may inhibit the metabolism of mebendazole in the liver, resulting in increased plasma concentrations of the drug especially during prolonged treatment.

Food Interaction

  • Take with or without food.

Mebendazole Disease Interaction

Moderate: liver disease

Elimination Route

Poorly absorbed (approximately 5 to 10%) from gastrointestinal tract. Fatty food increases absorption.

Half Life

2.5 to 5.5 hours (range 2.5 to 9 hours) in patients with normal hepatic function. Approximately 35 hours in patients with impaired hepatic function (cholestasis).

Elimination Route

In man, approximately 2% of administered mebendazole is excreted in urine and the remainder in the feces as unchanged drug or a primary metabolite.

Pregnancy & Breastfeeding use

Mebendazole should not be administered during pregnancy and in women thought to be pregnant. It is not known whether mebendazole or its metabolites are secreted in human breast milk. Thus Mebendazole should not be used during lactation unless the potential benefits are considered to outweigh the potential risk associated with treatment.


Mebendazole is contraindicated in pregnancy and in patients who have shown hypersensitivity to the product or any of its components.

Acute Overdose

Symptoms: Alopecia, reversible liver function disturbances, hepatitis, agranulocytosis, neutropenia, glomerulonephritis, abdominal cramps, nausea, vomiting and diarrhoea.

Management: Within the 1st hr after ingestion, gastric lavage may be performed. Activated charcoal may be given if considered appropriate.

Storage Condition

Store between 20-25° C.

Innovators Monograph

You find simplified version here Mebendazole

Mebendazole contains Mebendazole see full prescribing information from innovator Mebendazole Monograph, Mebendazole MSDS, Mebendazole FDA label


What is Mebendazole used for?

Mebendazole is a medication used to treat a number of parasitic worm infestations. This includes ascariasis, pinworm infection, guinea worm infections, hydatid disease, and giardia, among others. Mebendazole also is used to treat: Common roundworms (ascariasis), Hookworms (ancylostomiasis, necatoriasis, uncinariasis).

How safe is Mebendazole?

Mebendazole generally safe. Taking an extra dose of Mebendazole by accident is unlikely to cause any harm.

How does Mebendazole work?

Mebendazole works by stopping the worms using sugar (glucose).

What are the common side effects of Mebendazole?

Common side effects of Mebendazole are include;

  • diarrhea.
  • stomach pain, discomfort, or swelling.
  • nausea.
  • vomiting.
  • loss of appetite.

Is Mebendazole safe during pregnancy?

Mebendazole are well tolerated, with no adverse events in pregnant women and their fetuses when given after the first trimester of pregnancy.

Is Mebendazole safe during breastfeeding?

Mebendazole use during lactation is considered to be safe due to a low oral absorption and unlikely excretion in milk.

Can I drink alcohol with Mebendazole ?

Yes, you can drink alcohol with Mebendazole.

When should be best taken of Mebendazole?

Mebendazole is best taken with meals, especially fatty ones (eg, meals that include whole milk or ice cream). This helps to clear up the infection by helping your body absorb the medicine better.

How many time can I take Mebendazole daily?

Usually you need to take a dose 2 times a day for 3 days.

How long does Mebendazole take to work?

Mebendazole should start to work straight away but it may take several days to kill all the worms.

How long does Mebendazole stay in my system?

The apparent elimination half-life after an oral dose ranges from 3 to 6 hours in most patients.

How long can I take Mebendazole?

Mebendazole is usually taken as a single dose, but it can be taken for around 3 days for some infections. The most common side effect is stomach pain.

Who should not take Mebendazole?

Tell your doctor if you are pregnant or plan to become pregnant. Mebendazole can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine. Mebendazole is not approved for use by anyone younger than 2 years old.

What happens if I overdose?

Seek emergency medical attention. Overdose symptoms may include upper stomach pain, loss of appetite, dark urine, or jaundice (yellowing of the skin or eyes).

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Can Mebendazole cause liver damage?

Mebendazole when given for prolonged periods in high doses has been associated with elevations in serum enzyme levels, and rare instances of acute, clinically apparent liver injury have been linked to its use.

*** Taking medicines without doctor's advice can cause long-term problems.