Metocurine Iodide

Metocurine Iodide Uses, Dosage, Side Effects, Food Interaction and all others data.

Metocurine Iodide is a benzylisoquinolinium competitive nondepolarizing neuromuscular blocking agent. It is used as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy Metocurine Iodide has a moderate risk of inducing histamine release and has some ganglion blocking activity. Metocurine Iodide can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation. Metocurine Iodide is no longer available on the US market.

Metocurine Iodide is a benzylisoquinolinium competitive nondepolarizing neuromuscular blocking agent. Metocurine Iodide has a moderate risk of inducing histamine release and has some ganglion blocking activity. Metocurine Iodide can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation. As with other nondepolarizing neuromuscular blockers, the time to onset of paralysis decreases and the duration of maximum effect increases with increasing doses of metocurine iodide. Repeated administration of maintenance doses of metocurine iodide has no cumulative effect on the duration of neuromuscular block if recovery is allowed to begin prior to repeat dosing. Moreover, the time needed to recover from repeat doses does not change with additional doses. Repeat doses can therefore be administered at relatively regular intervals with predictable results.

Trade Name Metocurine Iodide
Generic Metocurine iodide
Metocurine iodide Other Names Dimethyl tubocurarine iodide, Dimethylchondrocurarine iodide, Dimethyltubocurarinium iodide, Metocurine iodide, Metocurini iodidum, Metubine iodide
Type
Formula C40H48I2N2O6
Weight Average: 906.6279
Monoisotopic: 906.160174118
Protein binding

35% in plasma

Groups Approved, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Metocurine Iodide
Metocurine Iodide

Uses

For use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.

How Metocurine Iodide works

Metocurine Iodide antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine, edrophonium, and pyridostigmine.

Toxicity

Excessive doses can be expected to produce enhanced pharmacological effects. Overdosage may increase the risk of histamine release and cardiovascular effects, especially hypotension.

Half Life

3 to 4 hours

Innovators Monograph

You find simplified version here Metocurine Iodide

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