Dimethyltubocurarinium Iodide

Dimethyltubocurarinium Iodide Uses, Dosage, Side Effects, Food Interaction and all others data.

Dimethyltubocurarinium Iodide is a benzylisoquinolinium competitive nondepolarizing neuromuscular blocking agent. It is used as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy Dimethyltubocurarinium Iodide has a moderate risk of inducing histamine release and has some ganglion blocking activity. Dimethyltubocurarinium Iodide can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation. Metocurine Iodide is no longer available on the US market.

Dimethyltubocurarinium Iodide is a benzylisoquinolinium competitive nondepolarizing neuromuscular blocking agent. Dimethyltubocurarinium Iodide has a moderate risk of inducing histamine release and has some ganglion blocking activity. Dimethyltubocurarinium Iodide can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation. As with other nondepolarizing neuromuscular blockers, the time to onset of paralysis decreases and the duration of maximum effect increases with increasing doses of metocurine iodide. Repeated administration of maintenance doses of metocurine iodide has no cumulative effect on the duration of neuromuscular block if recovery is allowed to begin prior to repeat dosing. Moreover, the time needed to recover from repeat doses does not change with additional doses. Repeat doses can therefore be administered at relatively regular intervals with predictable results.

Dimethyltubocurarinium Iodide
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Dimethyltubocurarinium Iodide
Generic	Metocurine iodide
Metocurine iodide Other Names	Dimethyl tubocurarine iodide, Dimethylchondrocurarine iodide, Dimethyltubocurarinium iodide, Metocurine iodide, Metocurini iodidum, Metubine iodide
Type
Formula	C₄₀H₄₈I₂N₂O₆
Weight	Average: 906.6279 Monoisotopic: 906.160174118
Protein binding	35% in plasma
Groups	Approved, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.

How Dimethyltubocurarinium Iodide works

Dimethyltubocurarinium Iodide antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine, edrophonium, and pyridostigmine.

Toxicity

Excessive doses can be expected to produce enhanced pharmacological effects. Overdosage may increase the risk of histamine release and cardiovascular effects, especially hypotension.