Masoprocolum

Masoprocolum Uses, Dosage, Side Effects, Food Interaction and all others data.

A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. [PubChem]

Masoprocolum is a novel antineoplastic agent. It is not known exactly how masoprocol works. Laboratory experiments have shown that masoprocol prevents cells similar to the ones found in actinic keratoses from multiplying. Masoprocolum was withdrawn from the U.S. market in June 1996.

Trade Name Masoprocolum
Generic Masoprocol
Masoprocol Other Names erythro-nordihydroguaiaretic acid, Masoprocol, Masoprocolum, meso-NDGA, meso-nordihydroguaiaretic acid, Nordihydroguaiaretic acid
Type
Formula C18H22O4
Weight Average: 302.3649
Monoisotopic: 302.151809192
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Masoprocolum
Masoprocolum

Uses

Used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated).

How Masoprocolum works

Although the exact mechanism of action is not known, studies have shown that masoprocol is a potent 5-lipoxygenase inhibitor and has antiproliferative activity against keratinocytes in tissue culture, but the relationship between this activity and its effectiveness in actinic keratoses is unknown. Masoprocolum also inhibits prostaglandins but the significance of this action is not yet known.

Toxicity

Symptoms of overdose or allergic reaction include bluish coloration of skin, dizziness, severe, or feeling faint, wheezing or trouble in breathing.

Elimination Route

Less than 1%-2% is absorbed through the skin over a 4-day period following application.

Innovators Monograph

You find simplified version here Masoprocolum

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0001392
http://classyfire.wishartlab.com/tax_nodes/C0001969
http://classyfire.wishartlab.com/tax_nodes/C0001969
http://classyfire.wishartlab.com/tax_nodes/C0002811
http://classyfire.wishartlab.com/tax_nodes/C0000135
http://classyfire.wishartlab.com/tax_nodes/C0004647
http://classyfire.wishartlab.com/tax_nodes/C0004646
http://classyfire.wishartlab.com/tax_nodes/C0000323
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:73468
http://www.genome.jp/dbget-bin/www_bget?cpd:C10719
http://www.hmdb.ca/metabolites/HMDB0014325
http://www.genome.jp/dbget-bin/www_bget?drug:D04862
http://www.genome.jp/dbget-bin/www_bget?cpd:C10719
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=71398
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508042
https://www.chemspider.com/Chemical-Structure.64490.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22372
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=227239
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=73468
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL313972
https://zinc.docking.org/substances/ZINC000000012342
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DNC001037
http://www.pharmgkb.org/drug/PA164746493
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4265
https://en.wikipedia.org/wiki/Masoprocol
*** Taking medicines without doctor's advice can cause long-term problems.
Share