Maphenidum

Maphenidum Uses, Dosage, Side Effects, Food Interaction and all others data.

Maphenidum is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.

Trade Name Maphenidum
Availability Prescription only
Generic Mafenide
Mafenide Other Names 4-Homosufanilamide, Bensulfamide, Mafenide, Maphenidum
Related Drugs lidocaine topical, vancomycin, gentamicin, tobramycin, Silvadene, Garamycin
Type
Formula C7H10N2O2S
Weight Average: 186.232
Monoisotopic: 186.046298264
Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Maphenidum
Maphenidum

Uses

Maphenidum is an antimicrobial topical agent indicated for use as an adjunctive treatment to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.

Indicated for use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.

Maphenidum is also used to associated treatment for these conditions: Second Degree Burns, Third Degree Burns

How Maphenidum works

The precise mechanism of mafenide is unknown. However, mafenide reduces the bacterial population in the avascular burn tissue and promotes spontaneous heeling of deep burns.

Toxicity

Since mafenide is metabolized to a carbonic anhydrase inhibitor, metabolic acidosis could occur.

Food Interaction

No interactions found.

Maphenidum Disease Interaction

Moderate: acid/base balance, hemolytic anemia/DIC

Elimination Route

Maphenidum is absorbed through devascularized areas into the systemic circulation following topical administration.

Elimination Route

Renal—Metabolite rapidly excreted in urine in high concentrations; however, the parent compound has not been detected in urine.

Innovators Monograph

You find simplified version here Maphenidum

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http://classyfire.wishartlab.com/tax_nodes/C0002448
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http://classyfire.wishartlab.com/tax_nodes/C0001585
http://classyfire.wishartlab.com/tax_nodes/C0003137
http://classyfire.wishartlab.com/tax_nodes/C0004557
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http://classyfire.wishartlab.com/tax_nodes/C0000469
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https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6572
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=6633
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL419
https://zinc.docking.org/substances/ZINC000000001644
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/6LH
https://www.drugs.com/international/Mafenide.html
https://en.wikipedia.org/wiki/Mafenide
*** Taking medicines without doctor's advice can cause long-term problems.
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