Mafenide
Mafenide Uses, Dosage, Side Effects, Food Interaction and all others data.
Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.
| Trade Name | Mafenide |
| Availability | Prescription only |
| Generic | Mafenide |
| Mafenide Other Names | 4-Homosufanilamide, Bensulfamide, Mafenide, Maphenidum |
| Related Drugs | lidocaine topical, vancomycin, gentamicin, tobramycin, Silvadene, Garamycin |
| Weight | 85mg/g, 5% |
| Type | Powder, For Topical Solution, Topical Cream, Topical Powder For Reconstitution |
| Formula | C7H10N2O2S |
| Weight | Average: 186.232 Monoisotopic: 186.046298264 |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Mafenide is an antimicrobial topical agent indicated for use as an adjunctive treatment to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.
Indicated for use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.
Mafenide is also used to associated treatment for these conditions: Second Degree Burns, Third Degree Burns
How Mafenide works
The precise mechanism of mafenide is unknown. However, mafenide reduces the bacterial population in the avascular burn tissue and promotes spontaneous heeling of deep burns.
Toxicity
Since mafenide is metabolized to a carbonic anhydrase inhibitor, metabolic acidosis could occur.
Food Interaction
No interactions found.Mafenide Disease Interaction
Elimination Route
Mafenide is absorbed through devascularized areas into the systemic circulation following topical administration.
Elimination Route
Renal—Metabolite rapidly excreted in urine in high concentrations; however, the parent compound has not been detected in urine.
Innovators Monograph
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