Levallorphanum

Levallorphanum Uses, Dosage, Side Effects, Food Interaction and all others data.

An opioid antagonist with properties similar to those of naloxone; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)

Levallorphanum, an opioid antagonist similar to naloxone, is used to treat drug overdoses. Levallorphanum differs from naloxone in that it also possesses some agonist properties. It is an analogue of levelorphanol that counteracts the actions of narcotic analgesics such as morphine. It is used especially in the treatment of respiratory depression due to narcotic overdoses. Levallorphanum prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.

Trade Name Levallorphanum
Generic Levallorphan
Levallorphan Other Names Levallofano, Levallorphan, Lévallorphane, Levallorphanum, Levalorfano
Type
Formula C19H25NO
Weight Average: 283.4079
Monoisotopic: 283.193614427
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Levallorphanum
Levallorphanum

Uses

For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.

How Levallorphanum works

Levallorphanum antagonizes opioid effects by competing for the same receptor sites. It binds to the opioid mu receptor and the nicotinic acetylcholine receptor alpha2/alpha3.

Toxicity

Oral, rat LD50: 109±4 mg/kg

Elimination Route

Rapidly absorbed.

Half Life

1 hour

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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