Fluopromazine

Fluopromazine Uses, Dosage, Side Effects, Food Interaction and all others data.

A phenothiazine used as an antipsychotic agent and as an antiemetic.

Fluopromazine is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists. Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. It reduces anxiety, emotional withdrawal, hallucinations, disorganized thoughts, blunted mood, and suspiciousness. Fluopromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can also be used to control severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Fluopromazine acts on the central nervous system.

Trade Name Fluopromazine
Availability Discontinued
Generic Triflupromazine
Triflupromazine Other Names Fluopromazine, Triflupromazin, Triflupromazina, Triflupromazine, Triflupromazinum
Type
Formula C18H19F3N2S
Weight Average: 352.417
Monoisotopic: 352.122103923
Protein binding

Very high (90% or more).

Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Fluopromazine
Fluopromazine

Uses

Used mainly in the management of psychoses. Also used to control nausea and vomiting.

How Fluopromazine works

Fluopromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Fluopromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Fluopromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT2B).

Toxicity

Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.

Fluopromazine Alcohol interaction

[Moderate] GENERALLY AVOID:

Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.

Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.

The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.



Patients should be advised to avoid alcohol during phenothiazine therapy.

Elimination Route

Absorption may be erratic and peak plasma concentrations show large interindividual differences.

Innovators Monograph

You find simplified version here Fluopromazine

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000002
http://classyfire.wishartlab.com/tax_nodes/C0000309
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http://classyfire.wishartlab.com/tax_nodes/C0003902
http://classyfire.wishartlab.com/tax_nodes/C0003864
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0001349
http://classyfire.wishartlab.com/tax_nodes/C0002239
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0001517
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001027
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:9711
http://www.hmdb.ca/metabolites/HMDB0014650
http://www.genome.jp/dbget-bin/www_bget?drug:D00390
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5568
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507344
https://www.chemspider.com/Chemical-Structure.5367.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67544
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=10805
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=9711
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL570
https://zinc.docking.org/substances/ZINC000000538507
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000294
http://www.pharmgkb.org/drug/PA451773
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4330
https://en.wikipedia.org/wiki/Triflupromazine
*** Taking medicines without doctor's advice can cause long-term problems.
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