D-thyroxine

D-thyroxine Uses, Dosage, Side Effects, Food Interaction and all others data.

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism.

D-thyroxine, the dextrorotary isomer of the synthetic thyroxine, is a antihyperlipidemic.

D-thyroxine
Uses
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	D-thyroxine
Generic	Dextrothyroxine
Dextrothyroxine Other Names	D-thyroxine, Dextrothyroxine, Dextrothyroxinum
Type
Formula	C₁₅H₁₁I₄NO₄
Weight	Average: 776.87 Monoisotopic: 776.686681525
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

D-thyroxine is a thyroid hormone used to treat hyperlipidemia.

Used to lower high cholesterol levels in the blood.

How D-thyroxine works

D-thyroxine is a antihyperlipidemic. The mechanism of action is not completely understood, but dextrothyroxine apparently acts in the liver to stimulate formation of low-density lipoprotein (LDL) and, to a much greater extent, to increase catabolism of LDL. This leads to increased excretion of cholesterol and bile acids via the biliary route into the feces, with a resulting reduction in serum cholesterol and LDL. D-thyroxine has no significant effect on high-density lipoproteins (HDL). Inherently, it will also bind to thyroid receptors and as it is a prohormone, it will bind as a substrate to iodide peroxidase.