Elucin Uses, Dosage, Side Effects, Food Interaction and all others data.

Elucin Lotion is a bacteriostatic macrolide antibiotic, but may be bactericidal in high concentrations. Although the mechanism by which topical erythromycin acts in reducing inflammatory lessions of Acne vulgaris is unknown, it is presummable due to its antibiotic action.

Elucin tablet inhibits microsomal protein synthesis in susceptible organisms by inhibiting the translocation process. Specific binding to the 50S subunit or 70S ribosome occurs in these organisms but there is no binding to the stable 80S mammalian ribosome. Elucin is active against many Grampositive bacteria, some Gram-negative bacteria and against mycoplasmas and chlamydia.

Macrolides, such as erythromycin, stop bacterial growth by inhibiting protein synthesis and translation, treating bacterial infections. Elucin does not exert effects on nucleic acid synthesis. This drug has been shown to be active against most strains of the following microorganisms, effectively treating both in vitro and clinical infections. Despite this, it is important to perform bacterial susceptibility testing before administering this antibiotic, as resistance is a common issue that may affect treatment.

A note on antimicrobial resistance, pseudomembranous colitis, and hepatotoxicity

Trade Name Elucin
Availability Prescription only
Generic Erythromycin
Erythromycin Other Names Abomacetin, Eritromicina, Erythromycin, Erythromycin A, Erythromycin C, érythromycine, Erythromycinum
Related Drugs amoxicillin, prednisone, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin
Type Tablet, Cream, Suspension
Formula C37H67NO13
Weight Average: 733.9268
Monoisotopic: 733.461241235
Protein binding

Erythromycin demonstrates 93% serum protein binding in the erythromycin propionate form. Another resource indicates that erythromycin protein binding ranges from 80 to 90%.

Groups Approved, Investigational, Vet approved
Therapeutic Class Topical antibiotics for Acne
Manufacturer Ind Swift Laboratories Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am


Elucin tablet is highly effective in the treatment of a wide variety of clinical infections, such as

  • Upper respiratory tract infections: Tonsillitis, peritonsillar abscess, pharyngitis, laryngitis, sinusitis, and secondary infections in cold and influenza.
  • Lower respiratory tract infections: Tracheitis, acute and chronic bronchitis. Mycoplasma pneumoniae (lobar pneumonia, broncho pneumonia, primary atypical pneumoniae), bronchiectasis.
  • Skin and soft tissue infections: Boils and carbuncles, paronychia, abscesses, pustular acne, impetigo, cellulitis, furuncolosis, erythrasma.
  • Veneral infections: Non-specific urethritis, syphilis (if the patient is allergic to penicillin).
  • Gastro-intestinal infections: Cholecystitis, Staphylococcal enterocolitis, infectious diarrhoea, & cholera.
  • Ear and oral infections: 0titis media and otitis externa, gingivitis, dental abscesses.
  • Prophylaxis: Pre-operative and post-operative, trauma, burns, rheumatic fever.
  • Other infections: Diphtheria, whooping cough.

For topical treatment of acne, pimples & bacterial skin infections susceptible to Elucin

Elucin is also used to associated treatment for these conditions: Acne, Acne Vulgaris, Acute Otitis Media caused by Haemophilus Influenzae, Acute pelvic inflammatory disease caused by Neisseria Gonorrheae Infection, Bacterial Infections, Chancroid, Chlamydia Trachomatis, Chlamydial ophthalmia neonatorum, Community Acquired Pneumonia (CAP), Diphtheria, Erythrasma, Gastroparesis, Granuloma Inguinale, Intestinal amebiasis caused by entamoeba histolytica, Legionella Pneumophila Infections, Listeria infection, Lower Respiratory Tract Infection (LRTI), Lymphogranuloma Venereum, Nongonococcal urethritis, Ophthalmia neonatorum (gonococcal), Pertussis, Postoperative Infections, Primary Syphilis, Respiratory Tract Infections (RTI), Staphylococcal Skin Infections, Syphilis, Upper Respiratory Tract Infection, Ureaplasma urethritis, Whooping Cough, Inflammatory papular lesions, Mild Acne vulgaris, Moderate Acne vulgaris, Predominant skin comedones, papules and pustules, Prophylaxis of Rheumatic fever, Pustular lesions, Skin and skin-structure infections, Skin and subcutaneous tissue bacterial infections caused by streptococcus pyogenes, Superficial ocular infections

How Elucin works

In order to replicate, bacteria require a specific process of protein synthesis, enabled by ribosomal proteins. Elucin acts by inhibition of protein synthesis by binding to the 23S ribosomal RNA molecule in the 50S subunit of ribosomes in susceptible bacterial organisms. It stops bacterial protein synthesis by inhibiting the transpeptidation/translocation step of protein synthesis and by inhibiting the assembly of the 50S ribosomal subunit. This results in the control of various bacterial infections. The strong affinity of macrolides, including erythromycin, for bacterial ribosomes, supports their broad‐spectrum antibacterial activities.


Elucin dosage

Adult and Child over 8 years: 250-500 mg every 6 hours or 0.5-1 gm every 12 hours. This may be increased up to 4 gm daily according to severity of infections.

Child of 2-8 years: 250 mg every 6 hours, doses doubled for severe infections.

Child up to 2 years: 125 mg every 6 hours.

Neonates: 30 to 45 mg/kg daily in 3 divided doses.

Elderly: Same as for adults.If administration on a twice daily schedule is desirable, one half of the total daily dose may be given every 12 hours, one hour before meal.

Amoebic dysentery:

  • Adult: 250 - 500 mg four times daily for 10 - 14 days.
  • Children: 30 - 50 mg/kg/day in divided doses for 10 - 14 days.

Pertussis: 30 - 50 mg/kg/day in divided doses for 5-14 days depending upon eradication of a positive culture.Streptococcal infections: In the treatment of group A beta haemolytic streptococcal infections, therapeutic dosage of Elucin should be administered for at least 10 days.

Acne: The usual dosage regimen of erythromycin in the treatment of acne is 500 mg twice daily for 3 months. Then the dose is to be reduced to 250 mg twice daily for another 3 months.

Early Syphilis: 500 mg 4 times daily for 14 days.Uncomplicated genital Chlamydia nongonococcal Urethritis: 500 mg twice daily for 14 days.

Prophylaxis: In continuous prophylaxis of streptococcal infections in person with a rheumatic heart disease, the dosage is 250 mg twice daily.

When Elucin is used prior to surgery to prevent endocarditis caused by alpha haemolytic streptococci, a recommended schedule:

  • For children: 20 mg/Kg 1.5 - 2 hours pre-operatively and 10 mg/kg every 6 hours for 8 doses post-operatively.
  • For adults:The dose is 1 g, 1.5 - 2 hours pre-operatively and 500 mg every 6 hours for 8 doses post-operatively.

Topical: Apply to the affected areas in the morning and evening. Before applying thoroughly wash with warm water and soap, rinse and pat dry all areas to be treated. Apply with applicator. Wash hands after use.

Direction for reconstitution of suspension: Shake the bottle to loosen powder. Add 60 ml (12 measuring spoonful) of boiled and cooled water to the dry powder of the bottle. For ease of preparation, add water to the bottle in two proportions. Shake well after each addition until all the powder is in suspension.

Note: Shake the suspension well before each use. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator and unused portion should be discarded after 7 days.

Side Effects

Generally erythromycin is well tolerated and serious adverse effects are rare. Side-effects are gastrointestinal and are dose-related. They include nausea, vomiting, abdominal pain, diarrhea and anorexia. Mild allergic reactions, such as urticaria and skin rashes have occurred. Serious allergic reactions, including anaphylaxis may occur.



The oral LD50 of erythromycin in rats is 9272 mg/kg.

Overdose information

Symptoms of overdose may include diarrhea, nausea, stomach cramps, and vomiting. Elucin should immediately be discontinued in cases of overdose. Rapid elimination of unabsorbed drug should be attempted. Supportive measures should be initiated. Elucin is not adequately removed by peritoneal dialysis or hemodialysis.


Lotion/Cream: For external use only. Keep away from eyes, nose, mouth and other mucous membrane.

Use of antibiotics (especially prolonged or repeated therapy) may result in bacterial or fungal overgrowth of non-susceptible organisms. Such overgrowth may lead to a secondary infection. Take appropriate measures if superinfections occur.

Tablet: Since Elucin is metabolized principally by the liver, caution should be exercised when erythromycin is administered to patients with impaired hepatic function. There have been reports of hepatic dysfunction with or without jaundice occurring in patients taking oral Elucin.


Theophylline: The use of Elucin in patients who are receiving concomitant high doses of theophylline may be associated with an increase in serum theophylline and potential theophylline toxicity. If symptoms of toxicity develop, the dose of theophylline should be reduced.

Digoxin: Concomitant administration of Elucin and Digoxin has been reported to result in elevated digoxin serum levels.

Clindamycin interacts with Elucin

Food Interaction

  • Avoid grapefruit products.
  • Take on an empty stomach. Allow approximately 30 minutes to 2 hours before meals, as this increases erythromycin absorption.
  • Take with a full glass of water.

[Moderate] ADJUST DOSING INTERVAL: Food may variably affect the bioavailability of different oral formulations and salt forms of erythromycin.

The individual product package labeling should be consulted regarding the appropriate time of administration in relation to food ingestion.

Grapefruit juice may increase the plasma concentrations of orally administered erythromycin.

The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits.

In an open-label, crossover study consisting of six healthy subjects, the coadministration with double-strength grapefruit juice increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of a single dose of erythromycin (400 mg) by 52% and 49%, respectively, compared to water.

The half-life was not affected.

The clinical significance of this potential interaction is unknown.

MANAGEMENT: In general, optimal serum levels are achieved when erythromycin is taken in the fasting state, one-half to two hours before meals.

However, some erythromycin products may be taken without regard to meals.

Elucin Alcohol interaction

[Minor] Ethanol, when combined with erythromycin, may delay absorption and therefore the clinical effects of the antibiotic.

The mechanism appears to be due to slowed gastric emptying by ethanol.

Data is available only for erythromycin ethylsuccinate.


should be advised to avoid ethanol while taking erythromycin salts.

Volume of Distribution

Elucin is found in most body fluids and accumulates in leucocytes and inflammatory liquid. Spinal fluid concentrations of erythromycin are low, however, the diffusion of erythromycin through the blood-brain barrier increases in meningitis, likely due to the presence of inflamed tissues which are easily penetrated. Elucin crosses the placenta.

Elimination Route

Orally administered erythromycin is readily absorbed. Food intake does not appear to exert effects on serum concentrations of erythromycin. Some interindividual variation exists in terms of erythromycin absorption, which may impact absorption to varying degrees. The Cmax of erythromycin is 1.8 mcg/L and the Tmax is 1.2 hours. The serum AUC of erythromycin after the administration of a 500mg oral dose was 7.3±3.9 mg.h/l in one pharmacokinetic study. Elucin is well known for a bioavailability that is variable (18-45%) after oral administration and its susceptibility to broken down under acidic conditions.

Half Life

The elimination half-life of oral erythromycin was 3.5 hours according to one study and ranged between 2.4-3.1 hours in another study. Repetitive dosing of erythromycin leads to increased elimination half-life.


The clearance of erythromycin in healthy subjects was 0.53 ± 0.13 l/h/kg after a 125mg intravenous dose. In a clinical study of healthy patients and patients with liver cirrhosis, clearance of erythromycin was significantly reduced in those with severe liver cirrhosis. The clearance in cirrhotic patients was 42.2 ± 10.1 l h–1 versus 113.2 ± 44.2 l h-1 in healthy patients.

Elimination Route

In patients with normal liver function, erythromycin concentrates in the liver and is then excreted in the bile.Under 5% of the orally administered dose of erythromycin is found excreted in the urine. A high percentage of absorbed erythromycin is not accounted for, but is likely metabolized.

Pregnancy & Breastfeeding use

Safety for use during pregnancy has not been established. Use only when the potential benefits outweigh potential hazards to the fetus.

Elucin is excreted in breast milk. Exercise caution when administering to a nursing mother.


Erythomycin is contraindicated in patients with a known hypersensitivity to this drug.

Special Warning

Safety and effectiveness in children less than 12 years have not been established.

Acute Overdose

In case of overdosage, Elucin should be discontinued. Overdosage should be handled with the prompt elimination of unabsorbed drug and all other appropriate measures should be instituted. Elucin is not removed by peritoneal dialysis or haemodialysis.

Storage Condition

Keep at room temperature and away from light.

Innovators Monograph

You find simplified version here Elucin

Elucin contains Erythromycin see full prescribing information from innovator Elucin Monograph, Elucin MSDS, Elucin FDA label


What is Elucin used for?

Elucin is an antibiotic used for the treatment of a number of bacterial infections. This includes respiratory tract infections, skin infections, chlamydia infections, pelvic inflammatory disease, and syphilis. It's widely used to treat chest infections, such as pneumonia, such as acne and rosacea, dental abscesses, and sexually transmitted infections. Elucin is used in children, often to treat ear infections or chest infections.

How safe is Elucin?

Elucin isn't suitable for certain people. To make sure Elucin is safe for you, tell your doctor if you have an allergic reaction to Elucin or other antibiotics in the past.

How does Elucin work?

Elucin works by stopping the growth of bacteria.

What are the common side effects of Elucin?

The most common side effects of Elucin are feeling or being sick (nausea or vomiting), stomach cramps and diarrhoea.

Is Elucin safe during pregnancy?

It's usually safe to take Elucin during pregnancy.

Is Elucin safe during breastfeeding?

Because of the low levels of Elucin in breastmilk and safe administration directly to infants, it is acceptable in nursing mothers. The small amounts in milk are unlikely to cause adverse effects in the infant.

Can I drink alcohol with Elucin?

There's no specific warning to stop drinking alcohol while taking Elucin, but there's some evidence that alcohol may slow down or delay the medicine working. You might want to stop drinking alcohol or limit how much you drink while you're taking.

Can I drive after taking Elucin?

Do not drive or operate heavy machinery until you know how Elucin affects you.

How often can I take Elucin?

Elucin usually is taken with or without food every 6 hours (four times a day), every 8 hours (three times a day), or every 12 hours (twice a day).

Can I take Elucin on an empty stomach?

Take Elucin on an empty stomach, at least 30 minutes before or 2 hours after food. If this medicine upsets your stomach, take with food or milk. Take your medicine at regular intervals. Do not take your medicine more often than directed.

How long does it take for Elucin to absorb?

Look downward, then gently close your eyes and keep them closed for 1 to 2 minutes to allow the medication to be absorbed.

How long does Elucin stay in my system?

The elimination half life is approximately 2 hours. Doses may be administered 2, 3 or 4 times a day.

Can Elucin be used long term?

Elucin is used to stop the growth of bacteria. Elucin is used to treat both acute (short-term) and chronic (long-term) bacterial infections.

How long should I take Elucin ?

Your doctor will advise you on how long to take Elucin for (usually 5 to 10 days), but depending on the infection, it could be longer.

Does Elucin affect the kidneys?

Elucin can influence kidney function secondary to interactions with other drugs.

Does Elucin make me tired?

Elucin can make you tired.

Can Elucin cause inflammation?

besides having antibacterial activity, also have an anti-inflammatory action.

Does Elucin raise blood pressure?

Treatment with Elucin was found to increase the risk of low blood pressure almost 6-fold.

Does Elucin cause anxiety?

No, taking an antibiotic doesn't cause anxiety or panic attacks.

Who should not take Elucin?

Elucin will not treat a viral infection such as the common cold or flu.Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Elucin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

What happens if I miss a dose?

Use Elucin as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happen if I take too much Elucin?

If you take too much Elucin, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. If Elucin is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur.

What happen If I just stop taking Elucin?

Do not stop taking Elucin without talking to your doctor. Stopping the medication too early may result in a return of the infection.

*** Taking medicines without doctor's advice can cause long-term problems.