Edetic Acid Calcium Disodium Salt

Edetic Acid Calcium Disodium Salt Uses, Dosage, Side Effects, Food Interaction and all others data.

Edetate calcium disodium is a metal ion chelator used to reduce blood concentrations and depot stores of lead from the body. It is on the World Health Organization Model List of Essential Medicines.

Edetate calcium disodium was granted FDA approval on 16 July 1953.

Edetate calcium disodium is a polyvalent ion chelator used to remove lead from the body after lead poisoning. It has a wide therapeutic index, as overdoses must be well in excess of the therapeutic dose to show symptoms. It has a long duration of action, as doses are given at least a day apart. Patients should be counselled regarding the risk of increased intracranial pressure with intravenous infusions.

Edetic Acid Calcium Disodium Salt
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Edetic Acid Calcium Disodium Salt
Generic	Edetate calcium disodium anhydrous
Edetate calcium disodium anhydrous Other Names	Edetic acid calcium disodium salt, Edetate calcium disodium
Type
Formula	C₁₀H₁₂CaN₂Na₂O₈
Weight	Average: 374.268 Monoisotopic: 374.001495875
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Edetate calcium disodium is a chelating agent used to treat lead poisoning.

Edetate calcium disodium is indicated to reduce blood levels and depot stores of lead in acute and chronic lead poisoning.

Edetic Acid Calcium Disodium Salt is also used to associated treatment for these conditions: Poisoning, Lead

How Edetic Acid Calcium Disodium Salt works

Edetate calcium disodium distributes into tissues, such as the kidney and bone, where it chelates lead ions. The lead ions are then eliminated in the normal urinary excretion of edetate. Lead in certain tissues such as the liver and bone, redistribute to other tissues after edetate calcium disodium treatment, but lead levels do not decrease to levels seen in unexposed patients.

Toxicity

Patients experiencing an overdose may present with similar symptoms to severe lead poisoning such as cerebral edema and renal tubular necrosis. Overdose can be managed through the administration of mannitol, zinc level monitoring, and maintenance of urinary output.

Food Interaction

No interactions found.

Volume of Distribution

The volume of distribution of edetate calcium disodium is 0.19±0.10L/kg.

Elimination Route

Calcium edetate disodium's C_max and AUC are dependant on renal function. 5% of an oral dose is absorbed from the gastrointestinal tract.

Half Life

The half life of edetate calcium disodium is 20-60 minutes.

Clearance

The mean clearance of edetate in 1 month olds is 54.6mL/min/1.73m². 2-17 year olds have a mean clearance of 113.9±24.4mL/min/1.73m²

Elimination Route

Edetate calcium disodium is 95% eliminated in the urine within 24 hours. An oral dose in rats was 88.32% recovered in the feces and 10.30% recovered in the urine.