Edetate disodium

Edetate disodium Uses, Dosage, Side Effects, Food Interaction and all others data.

Edetate disodium is a polyvalent chelating agent used to treat hypercalcemia and digitalis toxicity associated ventricular arrhythmias.

Edetate disodium is a polyvalent ion chelator that reduces blood concentrations of calcium or digitalis. It has a long duration of action as patients are generally given 1 daily dose. The therapeutic index is wide, as high doses are generally well tolerated. Patients should be counselled regarding the risk of postural hypotension, effects of myocardial contractility, hypokalemia, hypomagnesemia, and hypoglycemia.

Edetate disodium
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Edetate disodium
Generic	Edetate disodium anhydrous
Edetate disodium anhydrous Other Names	Edetate disodium
Type
Formula	C₁₀H₁₄N₂Na₂O₈
Weight	Average: 336.2063 Monoisotopic: 336.054554784
Groups	Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Edetate disodium is a polyvalent ion chelator indicated for emergency treatment of hypercalcemia and digitalis toxicity associated ventricular arrhythmias.

Edetate disodium is indicated for emergency treatment of hypercalcemia and digitalis toxicity associated ventricular arrhythmias.

Edetate disodium is also used to associated treatment for these conditions: Hypercalcemia, Arrhythmia of ventricular origin

How Edetate disodium works

Edetate disodium chelates divalent and trivalent ions such as magnesium, zinc, and calcium. The chelate is excreted in the urine, reducing concentrations of these ions in the blood.

Toxicity

Patients experiencing an overdose may present with calcium deficiency. Treat overdose with symptomatic and supportive treatment, which may include intravenous calcium gluconate.

Food Interaction

No interactions found.

Volume of Distribution

Data regarding the volume of distribution of edetate disodium anhydrous is not readily available.

Clearance

The mean clearance of edetate in 1 month olds is 54.6mL/min/1.73m². 2-17 year olds have a mean clearance of 113.9 ± 24.4 mL/min/1.73m²

Elimination Route

After intravenous administration, 95% of the dose is recovered in the urine after 24 hours. Oral administration in rats leads to 5.3% recovery in urine and 88.5% recovery in feces.