Dinoprostona

Dinoprostona Uses, Dosage, Side Effects, Food Interaction and all others data.

Dinoprostona is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.

Dinoprostona is equivalent to prostaglandin E2 (PGE2). It stimulates labor and delivery by stimulating the uterine, and thus terminates pregnancy. Dinoprostona is also capable of stimulating the smooth muscle of the gastrointestinal tract of man. This activity may be responsible for the vomiting and/or diarrhea that is not uncommon when dinoprostone is used to terminate pregnancy.

Trade Name Dinoprostona
Generic Dinoprostone
Dinoprostone Other Names (15S)-prostaglandin E2, Dinoproston, Dinoprostona, Dinoprostone, Dinoprostonum, PGE2, Prostaglandin E2
Type
Formula C20H32O5
Weight Average: 352.4651
Monoisotopic: 352.224974134
Protein binding

73%, to albumin

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Dinoprostona
Dinoprostona

Uses

Dinoprostona is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease.

For the termination of pregnancy during the second trimester (from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period), as well as for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period. Also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole). Other indications include improving the cervical inducibility (cervical "ripening") in pregnant women at or near term with a medical or obstetrical need for labor induction, and the management of postpartum hemorrhage.

Dinoprostona is also used to associated treatment for these conditions: Gestational Trophoblastic Disease, Induction of cervix ripening therapy, Medically induced abortion, Uterus evacuation

How Dinoprostona works

Dinoprostona administered intravaginally stimulates the myometrium of the gravid uterus to contract in a manner that is similar to the contractions seen in the term uterus during labor, resulting in the evacuation of the products of conception from the uterus. It is believed that dinoprostone exerts its uterine effects via direct myometrial stimulation, but the exact mechanism of action is unkown. Other suggested mechanisms include the regulation of cellular membrane calcium transport and of intracellular concentrations of cyclic 3',5'-adenosine monophosphate. Dinoprostona also appears to produce local cervical effects including softening, effacement, and dilation. The exact mechanism of action for this effect is also unknown, but it has been suggested that this effect may be associated with collagen degradation caused by secretion of the enzyme collagenase as a partial response to locally administered dinoprostone.

Toxicity

Oral, mouse: LD50 = 750 mg/kg; Oral, rat: LD50 = 500 mg/kg.

Food Interaction

No interactions found.

Elimination Route

Absorbed at a rate of 0.3 mg per hour over 12 hours while the vaginal system is in place.

Half Life

Less than 5 minutes.

Elimination Route

The major route of elimination of the products of PGE2 metabolism is the kidneys.

Innovators Monograph

You find simplified version here Dinoprostona

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000012
http://classyfire.wishartlab.com/tax_nodes/C0003909
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http://classyfire.wishartlab.com/tax_nodes/C0002949
http://classyfire.wishartlab.com/tax_nodes/C0000341
http://classyfire.wishartlab.com/tax_nodes/C0000339
http://classyfire.wishartlab.com/tax_nodes/C0002938
http://classyfire.wishartlab.com/tax_nodes/C0003487
http://classyfire.wishartlab.com/tax_nodes/C0001292
http://classyfire.wishartlab.com/tax_nodes/C0001137
http://classyfire.wishartlab.com/tax_nodes/C0001205
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15551
http://www.genome.jp/dbget-bin/www_bget?cpd:C00584
http://www.lipidmaps.org/data/LMSDRecord.php?LMID=LMFA03010003
http://www.hmdb.ca/metabolites/HMDB0001220
http://www.genome.jp/dbget-bin/www_bget?drug:D00079
http://www.genome.jp/dbget-bin/www_bget?cpd:C00584
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5280360
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505549
https://www.chemspider.com/Chemical-Structure.4444059.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35847
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3478
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=15551
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL548
https://zinc.docking.org/substances/ZINC000003830713
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000360
http://www.pharmgkb.org/drug/PA449345
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1916
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/P2E
http://www.rxlist.com/cgi/generic/dinoprostone.htm
https://www.drugs.com/cdi/dinoprostone-gel.html
https://en.wikipedia.org/wiki/Prostaglandin_E2
*** Taking medicines without doctor's advice can cause long-term problems.
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