Dichlorophenamide

Dichlorophenamide Uses, Dosage, Side Effects, Food Interaction and all others data.

A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.

Dichlorphenamide is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow).

Trade Name Dichlorophenamide
Generic Diclofenamide
Diclofenamide Other Names Dichlofenamide, Dichlorophenamide, Dichlorphenamide, Diclofenamida, Diclofenamide, Diclofenamidum
Type
Formula C6H6Cl2N2O4S2
Weight Average: 305.159
Monoisotopic: 303.914603484
Protein binding

55%

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Dichlorophenamide
Dichlorophenamide

Uses

Dichlorophenamide is a carbonic anhydrase inhibitor used for the management of open-angle and secondary glaucoma, as well as acute angle-closure glaucoma in delayed pre-operative setting requiring a reduction in intraocular pressure.

For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure

Dichlorophenamide is also used to associated treatment for these conditions: Hypokalemic Periodic Paralysis, Increased Intra Ocular Pressure (IOP), Paralysis, Hyperkalemic Periodic

How Dichlorophenamide works

Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow), although the mechanism by which they do this is not fully understood. Evidence suggests that HCO3- ions are produced in the ciliary body by hydration of carbon dioxide under the influence of carbonic anhydrase and diffuse into the posterior chamber which contains more Na+ and HCO3- ions than does plasma and consequently is hypertonic. Water is then attracted to the posterior chamber by osmosis, resulting in a drop in pressure.

Food Interaction

  • Increase consumption of potassium-rich foods. Dichlorophenamide may cause hypokalemia, therefore consuming more potassium-rich foods may help prevent hypokalemia.

Innovators Monograph

You find simplified version here Dichlorophenamide

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0002279
http://classyfire.wishartlab.com/tax_nodes/C0000031
http://classyfire.wishartlab.com/tax_nodes/C0000031
http://classyfire.wishartlab.com/tax_nodes/C0004233
http://classyfire.wishartlab.com/tax_nodes/C0002564
http://classyfire.wishartlab.com/tax_nodes/C0001585
http://classyfire.wishartlab.com/tax_nodes/C0001030
http://classyfire.wishartlab.com/tax_nodes/C0003137
http://classyfire.wishartlab.com/tax_nodes/C0001516
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004707
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:101085
http://www.hmdb.ca/metabolites/HMDB0015275
http://www.genome.jp/dbget-bin/www_bget?drug:D00518
http://www.genome.jp/dbget-bin/www_bget?cpd:C07459
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3038
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505039
https://www.chemspider.com/Chemical-Structure.2930.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10883
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3353
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=101085
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL17
https://zinc.docking.org/substances/ZINC000000896918
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000601
http://www.pharmgkb.org/drug/PA164745512
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/I7A
http://www.rxlist.com/cgi/generic/dichlorphen.htm
https://www.drugs.com/mtm/dichlorphenamide.html
https://en.wikipedia.org/wiki/Diclofenamide
*** Taking medicines without doctor's advice can cause long-term problems.
Share