Aldesulphone

Aldesulphone Uses, Dosage, Side Effects, Food Interaction and all others data.

Aldesulphone is a water-soluble sulfone used as an antileprosy drug. It has been used with limited success in the treatment of dermatitis herpetiformis.

Aldesulphone is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Trade Name Aldesulphone
Generic Sulfoxone
Sulfoxone Other Names Aldesulfone, Aldesulphone
Type
Formula C14H16N2O6S3
Weight Average: 404.482
Monoisotopic: 404.017048324
Protein binding

69%

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Aldesulphone
Aldesulphone

Uses

For the treatment of leprosy and dermatitis herpetiformis

How Aldesulphone works

Aldesulphone is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal substrate for the enzyme, para-aminobenzoic acid (PABA) cannot bind as usual. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

Toxicity

Oral, rat LD50: 7000 mg/kg

Elimination Route

Rapidly absorbed.

Half Life

3-8 hours

Innovators Monograph

You find simplified version here Aldesulphone

*** Taking medicines without doctor's advice can cause long-term problems.
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