Clocortolonum
Clocortolonum Uses, Dosage, Side Effects, Food Interaction and all others data.
Clocortolonum is a medium potency corticosteroid that is often used as a topical cream for the relief of inflammatory oand pruritic (itching) arising from steroid-responsive dermatoses of the scalp.
Like other topical corticosteroids, clocortolone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Clocortolonum is a moderate potency topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.
| Trade Name | Clocortolonum |
| Availability | Prescription only |
| Generic | Clocortolone |
| Clocortolone Other Names | Clocortolon, Clocortolona, Clocortolone, Clocortolonum |
| Related Drugs | Humira, Cosentyx, Dupixent, prednisone, methotrexate, Remicade, Stelara, cyclosporine, infliximab, Temovate |
| Type | |
| Formula | C22H28ClFO4 |
| Weight | Average: 410.907 Monoisotopic: 410.166015296 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Clocortolonum is a corticosteroid used to treat inflammatory and pruritic dermatoses of the scalp.
For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
Clocortolonum is also used to associated treatment for these conditions: Dermatosis
How Clocortolonum works
The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. These enzyme transcriptional changes are mediated by the drug binding first to the glucocorticoid receptor. This complex can migrate to the cell nucleus which then binds to DNA initiating genetic activation and repression of various genes.
Toxicity
Topically applied clocortolone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
Food Interaction
No interactions found.Clocortolonum Disease Interaction
Moderate: diabetes, diaper rash, hyperadrenocorticism, infections, ocular toxicities
Elimination Route
Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.
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