Chlorcyclizinum

Chlorcyclizinum Uses, Dosage, Side Effects, Food Interaction and all others data.

Chlorcyclizinum is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizinum also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can be used as an antiemetic.

Trade Name Chlorcyclizinum
Availability Over the counter
Generic Chlorcyclizine
Chlorcyclizine Other Names Chlorcyclizin, Chlorcyclizine, Chlorcyclizinum, Clorciclicina, Clorciclizina, Clorciclizinio
Related Drugs prednisone, cetirizine, loratadine, fluticasone nasal, promethazine, Zyrtec
Type
Formula C18H21ClN2
Weight Average: 300.826
Monoisotopic: 300.139326389
Protein binding

about 85 to 90%.

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Chlorcyclizinum
Chlorcyclizinum

Food Interaction

  • Avoid excessive or chronic alcohol consumption. Alcohol may increase the drowsiness caused by chlorcyclizine.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Volume of Distribution

After a single oral dose of 2 mg/kg to 4 subjects, average peak plasma concentrations of about 0.05 mg/L and 0.03 mg/L were attained in 5 h for unchanged drug and norchlorcyclizine, respectively. After oral administration of 50 mg 3 times a day for 6 days, plasma concentrations of norchlorcyclizine of 0.05 to 0.11 mg/L were reported on the first day after the cessation of treatment and plasma concentrations of 0.02 to 0.04 mg/L were found on the 10th day after cessation of treatment [Kuntzman et al. 1973].

Elimination Route

Readily absorbed after oral administration and widely distributed throughout the body. Metabolised by N-demethylation to form norchlorcyclizine and by N-oxidation.

Half Life

about 12 h.

Elimination Route

Slowly excreted in the urine; measurable amounts of norchlorcyclizine have been detected in the urine for up to 3 weeks after the cessation of chronic oral administration. About 0.5% of a single dose is excreted in the urine as the N-oxide.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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