Ceruletide

Ceruletide Uses, Dosage, Side Effects, Food Interaction and all others data.

Caerulein is a specific decapeptide similar in action and composition to the natural gastrointestinal peptide hormone cholecystokinin. It exerts stimulatory effects on the gastric, biliary, and pancreatic secretion, as well as on certain smooth muscles.

Caerulein is a specific decapeptide similar in action and composition to the natural gastrointestinal peptide hormone cholecystokinin that stimulates gastric, biliary, and pancreatic secretion. It also exerts stimulatory actions on certain smooth muscles.

Trade Name Ceruletide
Generic Ceruletide
Ceruletide Other Names Caerulein, Cerulein, Ceruletida, Ceruletide, Ceruletidum
Type
Formula C58H73N13O21S2
Weight Average: 1352.405
Monoisotopic: 1351.448537843
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Ceruletide
Ceruletide

Uses

Caerulein is used in the treatment of paralytic ileus and as diagnostic aid in pancreatic malfunction.

How Ceruletide works

Caerulein acts according to its similarity to the natural gastrointestinal peptide hormone cholecystokinin. Cholecystokinin is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. Cholecystokinin is secreted by the duodenum, the first segment of the small intestine. There it binds to CCK receptors, activating them and causing downstream effects. Specifically, it results in the release of digestive enzymes and bile from the pancreas and gall bladder, respectively. It also acts as a hunger suppresant. Cholecystokinin is secreted by the duodenum when fat- or protein-rich chyme leaves the stomach and enters the duodenum. The hormone acts on the pancreas to stimulate the secretion of the enzymes lipase, amylase, trypsin, and chymotrypsin. Together these pancreatic enzymes catalyze the digestion of fat and protein. Cholecystokinin also stimulates both the contraction of the gall bladder, and the relaxtion of the Sphincter of Oddi (Glisson's Sphinctor), which delivers, (not secretes) bile into the small intestine. Bile salts serve to emulsify fats, thereby increasing the effectiveness with which enzymes can digest them.

Elimination Route

Absorbed following intravenous administration.

Innovators Monograph

You find simplified version here Ceruletide

*** Taking medicines without doctor's advice can cause long-term problems.
Share