Gentian Violet(1+)

Gentian Violet(1+) Uses, Dosage, Side Effects, Food Interaction and all others data.

A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.

Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.

Trade Name Gentian Violet(1+)
Generic Gentian violet cation
Gentian violet cation Other Names Crystal Violet, Crystal violet(1+), Gentian violet cation, Gentian violet(1+), Methylrosaniline, Methylrosanilinium, Gentian Violet
Type
Formula C25H30N3
Weight Average: 372.5258
Monoisotopic: 372.243972975
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Gentian Violet(1+)
Gentian Violet(1+)

Uses

Gentian Violet is an antiseptic violet dye used to prevent various infections, including fungal and bacterial infections.

For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).

Gentian Violet(1+) is also used to associated treatment for these conditions: Bacterial Infection of the umbilical cord area, Fungal Infection of the umbilical cord area, Infection, Infections, Fungal

How Gentian Violet(1+) works

In aqueous solutions Gentian violet (GV) dissociates into positive (GV+)and negative ions (Cl-) that penetrate through the wall and membrane of both gram-positive and gram-negative bacterial cells. The GV+ interacts with negatively charged components of bacterial cells including the lipopolysaccharide (on the cell wall), the peptidoglycan and DNA. A similar cell penetration and DNA binding process is thought to take place for fungal cells as well. Because Gentian violet is a mutagen and mitotic poison, cell growth is consequently inhibited. A photodynamic action of gentian violet, apparently mediated by a free-radical mechanism, has recently been described in bacteria and in the protozoan T. cruzi. Evidence also suggests that gentian violet dissipates the bacterial (and mitochondrial) membrane potential by inducing permeability. This is followed by respiratory inhibition. This anti-mitochondrial activity might explain gentian violet's efficacy towards both bacteria and yeast with relatively mild effects on mammalian cells.

Toxicity

LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.

Food Interaction

No interactions found.

Innovators Monograph

You find simplified version here Gentian Violet(1+)

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0002279
http://classyfire.wishartlab.com/tax_nodes/C0000369
http://classyfire.wishartlab.com/tax_nodes/C0000369
http://classyfire.wishartlab.com/tax_nodes/C0003901
http://classyfire.wishartlab.com/tax_nodes/C0000284
http://classyfire.wishartlab.com/tax_nodes/C0002375
http://classyfire.wishartlab.com/tax_nodes/C0002393
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0003609
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:77181
http://www.hmdb.ca/metabolites/HMDB0014550
http://www.genome.jp/dbget-bin/www_bget?drug:D01046
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3468
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505353
https://www.chemspider.com/Chemical-Structure.3349.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052802
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1546369
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=77181
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL459265
https://zinc.docking.org/substances/ZINC000013763987
http://www.pharmgkb.org/drug/PA449755
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/CVI
https://www.drugs.com/cons/gentian-violet-topical.html
https://en.wikipedia.org/wiki/Gentian_Violet
*** Taking medicines without doctor's advice can cause long-term problems.
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