Caspofungina Uses, Dosage, Side Effects, Food Interaction and all others data.

Caspofungina (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal cell wall.

Caspofungina is an antifungal drug, and belongs to a new class termed the echinocandins. It is used to treat Aspergillus and Candida infection, and works by inhibiting cell wall synthesis. Antifungals in the echinocandin class inhibit the synthesis of glucan in the cell wall, probably via the enzyme 1,3-beta glucan synthase. There is a potential for resistance development to occur, however in vitro resistance development to Caspofungina by Aspergillus species has not been studied.

Trade Name Caspofungina
Availability Prescription only
Generic Caspofungin
Caspofungin Other Names Caspofungin, Caspofungina
Related Drugs ciprofloxacin, fluconazole, Augmentin, amoxicillin / clavulanate, vancomycin, gentamicin, Diflucan, itraconazole, amphotericin b, voriconazole
Formula C52H88N10O15
Weight Average: 1093.331
Monoisotopic: 1092.643062174
Protein binding


Groups Approved
Therapeutic Class
Available Country
Last Updated: September 19, 2023 at 7:00 am


Caspofungina is an echinocandin used to treat a variety of fungal infections.

For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.

Caspofungina is also used to associated treatment for these conditions: Abscess, Intra-Abdominal, Candidemia, Esophageal Candidiasis, Infections, Fungal, Oropharyngeal Candidiasis, Peritonitis, Invasive, refractory Aspergillosis, Pleural space infections

How Caspofungina works

Caspofungina inhibits the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of Aspergillus species and Candida species. beta-(1,3)-D-glucan is not present in mammalian cells. The primary target is beta-(1,3)-glucan synthase.


Side effects include rash, swelling, and nausea (rare)

Food Interaction

No interactions found.

Caspofungina Disease Interaction

Moderate: liver disease, hepatotoxicity

Elimination Route

92% tissue distribution within 36-48 hours after intravenous infusion

Half Life

9-11 hours


  • 12 mL/min [After single IV administration]

Elimination Route

After single intravenous administration of [3H] caspofungin acetate, excretion of caspofungin and its metabolites in humans was 35% of dose in feces and 41% of dose in urine.

Innovators Monograph

You find simplified version here Caspofungina

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