Arinet Tablet

Arinet is a potent and rapidly-acting blood schizontocide derived from the leaves of the chinese herb, Armesia annua. The exact mode of action is not clear but clinical studies have confirmed the effectiveness of artesunate in P. vivax and falciparum malaria.

Uses

Arinet can quickly and reliably control the acute attack of malaria. It is suitable to salvage the patients with pernicious malaria and treat P. falciparum malaria and P. vivax malaria. It is effective against malaria caused by chloroquine resistant strain of plasmodium falciparum.

Arinet is also used to associated treatment for these conditions: Acute Uncomplicated Plasmodium Falciparum Malaria, Malaria, Cerebral, Severe Malaria

Trade Name Arinet
Generic Artesunate
Other Names Artesunate, Artesunato, Artesunatum, Artesunic acid
Weight 50mg
Type Tablet
Formula C19H28O8
Weight Average: 384.425
Monoisotopic: 384.178417862
Protein binding

Artesunate and its metabolite DHA are approximately 93% protein bound in plasma. Artesunate can bind to serum albumin.

Therapeutic Class Anti-malarial drugs
Manufacturer Alco Pharma Ltd
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:16 am

Dosage

Arinet dosage

Adult: 5 days treatment: on the 1st day 2 tablets twice and 2nd day onward 1 tablet twice daily for remaining 4 days

Children

  • 1-3 years: 5 days treatment: on the 1st day ½ tablet twice and 2nd day onward ¼ tablet twice daily for remaining 4 days
  • 4-5 years: 5 days treatment: on the 1st day 1 tablet twice and 2nd day onward ½ tablet twice daily for remaining 4 days
  • 6-12 years: 5 days treatment: on the 1st day ½ tablet twice, 2nd day 1 tablet twice and 3rd day onward ½ tablet twice daily for remaining 3 days

Prophylmcis: 100 mg tablet once a week, from 1 week before entering malarial areas, to 4 weeks after leaving the area.

Side Effects

Transient and reversible reticulocytopaenia, drug fever, rash, bradycardia, transient 1st-degree heart block and reversible elevation of serum transaminases.

Precaution

Hepatic or renal insufficiency; Pregnancy and lactation.

Interaction

Antimalarial potentiating action seen with mefloquine, primaquine and tetracycline. Additive effect with chloroquine. Antagonistic effect with pyrimethamine and sulphonamides.

Food Interaction

No interactions found.

Volume of Distribution

The volume of distribution of artesunate is 68.5L while the volume of distribution of DHA is 59.7L.

Half Life

The elimination half life of artesunate is 0.3h with a range of 0.1-1.8h. The elimination half life of DHA is 1.3h with a range of 0.9-2.9h. Half life after intramuscular administration is 48 min in children and 41 min in adults.

Clearance

The clearance of artesunate is 180L/h while the clearance of DHA is 32.3L/h.

Pregnancy & Breastfeeding use

Pregnancy category is not classified. FDA has yet not classified the drug into a specific pregnancy catagory.

Contraindication

Hypersensitivity.

Arinet contains Artesunate see full prescribing information from innovator Monograph