aprelex

aprelex Uses, Dosage, Side Effects, Food Interaction and all others data.

aprelex is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).

aprelex is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It was shown to affect platelet aggregation, but whether this effect contributes to its vasodilatory action has not been elucidated. There are two diastereoisomers of iloprost and the 4S isomer is reported to exhibit a higher potency in dilating blood vessels compared to the 4R isomer.

Table Of contents

• aprelex
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	aprelex
Availability	Prescription only
Generic	Iloprost
Iloprost Other Names	Iloprost
Related Drugs	sildenafil, tadalafil, Revatio, Adempas, Opsumit, ambrisentan
Weight	20µg/ml
Type	Inhalation Solution
Formula	C22H32O4
Weight	Average: 360.494 Monoisotopic: 360.23005951
Protein binding	60%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer	Tabuk Pharmaceutical Manufacturing Co,
Available Country	Saudi Arabia
Last Updated:	September 19, 2023 at 7:00 am

Uses

aprelex is a synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH).

Used for the treatment of pulmonary arterial hypertension.

aprelex is also used to associated treatment for these conditions: NYHA class III Pulmonary arterial hypertension, NYHA class IV Pulmonary arterial hypertension

How aprelex works

aprelex is a second generation structural analog of prostacyclin (PGI) with about ten-fold greater potency than the first generation stable analogs, such as carbaprostacyclin. aprelex binds with equal affinity to human prostacyclin (Prostanoid IP) and prostaglandin EP1 receptors. aprelex constricts the ilium and fundus circular smooth muscle as strongly as prostaglandin E2 (PGE2) itself. aprelex inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time. All of these properties help to antagonize the pathological changes that take place in the small pulmonary arteries of patients with pulmonary hypertension.

Toxicity

Overdoses can lead to hypotension, headache, flushing, nausea, vomiting, and diarrhea.

Food Interaction

• Avoid herbs and supplements with anticoagulant/antiplatelet activity. Taking iloprost with anticoagulant/antiplatelet herbs may increase the risk of bleeding occurring as an adverse effect. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

aprelex Drug Interaction

Moderate: aspirin, aspirin, epinephrine, epinephrine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acidsUnknown: charcoal, charcoal, amoxicillin / clavulanate, amoxicillin / clavulanate, Allergy , Allergy , ubiquinone, ubiquinone, glucose, glucose, sodium iodide, sodium iodide, acetaminophen, acetaminophen

aprelex Disease Interaction

Major: hypotensionModerate: bronchospasm

Volume of Distribution

• 0.7 to 0.8 L/kg

Elimination Route

Rapidly absorbed with bioavailability of 63%

Half Life

20-30 minutes

Clearance

• 20 mL/min/kg [Normal subjects]

Innovators Monograph

You find simplified version here aprelex