Aldew is a member of the Benzimidazole group of anthelmintic agents which is an ideal broad spectrum anthelmintic. Aldew inhibits polymerization of tubulin causes loss of cytoplasmic microtubules that leads to impaired uptake of glucose, depletes glycogen stores, degenerative change in the endoplasmic reticulum and mitochondria & decrease production of ATP. It also inhibits the enzyme fumarate reductase which is a co-enzyme in many cellular oxidation-reduction reactions result no energy production and immobilization and death of parasites.
Aldewis used as anthelmintic against most nematodes and cestodes. It is effective against these gastro-intestinal parasites Bunostomum, Chabertia, Cooperia, Haemonchus, Ostertagia, Nematodirus, Strongyloides, Dictyocaulusviviparus, Monieziaexpansa, Liver flukes and Paramphistomes. It is also effective against different types of worms, lung flukes and lung nematodes.
Aldew is also used to associated treatment for these conditions: Ascariasis, Hookworm Infection, Hydatid disease caused by Echinococcus granulosus, Neurocysticercosis caused by Taenia solium, Other specified protozoal diseases
|Other Names||Albendazol, Albendazole, Albendazolum, Eskazole, Proftril|
70% bound to plasma protein
|Manufacturer||Doctor’s Chemical Works Ltd|
|Last Updated:||June 23, 2021 at 11:16 am|
Table Of contents
To keep animal free from helminths animal should be treated at 3 months interval.
Cattle & Buffalo: 7.5-10 mg/kg body weight or 14 bolus for 30-40 kg body weight, 12 bolus for 60-80 kg body weight & 1 boli for 120-160 kg body weight.
Goat & Sheep: 5-7.5 mg/kg body weight or 112 bolus for 13-20 kg body weight & 1 6 bolus for 27-40 kg body weight.
Dog & Cat: 15 mg/kg body weight or 18 bolus for 8-10 kg body weight & 14 bolus for 16-20 kg body weight.
Or as directed by the registered Veterinarian.
Aldew is time tested and clinically proven well tolerated drug. Established wide safety margin than any other anthelmentic due to greater selective affinity for parasitic b-tubulin than for animal tissues. However, in some cases nausea and vomiting may occur.
Before using Aldew inform the registered Veterinarian that your animals are not allergic to it; or to other benzimidazole anthelmintic drugs (e.g. Mebendazole).
Aldew has been shown to induce liver enzymes of the cytochrome P-450 system responsible for its own metabolism. There is, therefore, a theoretical risk of interaction with theophylline, anticonvulsants, anticoagulants, oral contraceptives and oral hypoglycaemics. Care should therefore be exercised during the introduction of Aldew in patients receiving the above groups of compounds
- Take with a high fat meal. A high fat meal increases solubility and absorption. Take with food when treating systemic infections.
Terminal elimination half-life ranges from 8 to 12 hours (single dose, 400mg).
Pregnancy & Breastfeeding use
Aldew should not use first 45 days of pregnancy of cow. Do not administer to ewes or does during the first 30 days of pregnancy. Sufficient data on use during lactation is not available. Therefore breast feeding should be discontinued during and for a minimum of 5 days after treatment.
This is known to be teratogenic and embryo-toxic in some animals. Therefore it should not be administered during pregnancy or in women thought to be pregnant. It should only be used in the treatment of echinococcosis if there is constant medical supervision with regular monitoring of serumtransaminase concentrations and of leucocyte and platelet counts.
If poisoning or excessive overdosageis suspected, it is recommended for vomiting be induction or gastric lavage and such symptomatic supportive therapy to be administered.
Interaction with other Medicine
Cimetidine, Praziquantel and Dexamethasone have been reported to increase the plasma levels of Aldew active metabolite.
Do not store above 30 degree centigrade. Keep away from light and out of the reach of children.