Alater Tablet

Alater is a potent and highly selective antagonist of the peripheral histamine H1-receptor on effector cells in the GI tract, blood vessels and respiratory tract.

Uses

Alater is used for the treatment of seasonal allergic rhinitis and conjunctivitis, perennial allergic rhinitis, pruritus and urticaria. It is also used in allergen induced asthma.

Alater is also used to associated treatment for these conditions: Chronic Idiopathic Urticaria, Flu caused by Influenza, Perennial Allergic Rhinitis (PAR), Pollen Allergy, Respiratory Allergy, Seasonal Allergic Rhinitis

Trade Name Alater
Generic Cetirizine
Other Names Cetirizin, Cetirizina, Cetirizine, Cetirizinum
Weight 10mg
Type Tablet
Formula C21H25ClN2O3
Weight Average: 388.888
Monoisotopic: 388.155370383
Protein binding

The mean plasma protein binding of cetirizine is 93% .

Therapeutic Class Sedating Anti-histamine
Manufacturer Bengal drugs Ltd
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:18 am

Dosage

Alater dosage

Tablet:

  • Adults and children over 6 years: 1 tablet (10 mg) once daily or ½ tablet twice daily.
  • Children 2-6 years: ½ tablet once daily.

Syrup:

  • Adults and children over 6 years: 2 teaspoonful (10 mg) once daily or 1 teaspoon (5 mg) twice daily.
  • Children 2-6 years: 1 teaspoonful once daily or ½ teaspoon twice daily.

Side Effects

Alater dihydrochloride is well tolerated. Lower incidence of sedation, headache, dry mouth, and gastrointestinal disturbances may occur. It does not produce anticholinergic effects.

Precaution

Caution should be exercised when driving a car or operating a heavy machinery. Concurrent use of cetirizine with alcohol or other CNS depressants should be avoided because additional reduction in alertness and CNS performance may occur.

Interaction

No clinically significant drug interactions have been found with theophylline, azithromycin, pseudoephedrine, ketoconazole or erythromycin and with some other drugs.

Food Interaction

  • Avoid alcohol.
  • Take with or without food. The absorption is unaffected by food.

Volume of Distribution

Apparent volume of distribution: 0.44 +/- 0.19 L/kg .

Half Life

Plasma elimination half-life is 8.3 hours .

Clearance

Apparent total body clearance: approximately 53 mL/min .

Alater is mainly eliminated by the kidneys , . Dose adjustment is required for patients with moderate to severe renal impairment and in patients on hemodialysis .

Pregnancy & Breastfeeding use

Pregnancy category B. There are no adequate and well controlled studies in pregnant women. Alater should be used during pregnancy only if clearly needed. Alater has been reported to be excreted in human breast milk. As large amount of drugs are excreted in human milk, use of Alater in nursing mother is not recommended.

Contraindication

Alater Dihydrochloride is contraindicated in those patients with a known hypersensitivity to it or any of its ingredients or hydroxyzine.

Acute Overdose

Symptoms: Confusion, dizziness, fatigue, headache, malaise, restlessness, sedation, somnolence, diarrhoea, mydriasis, pruritus, stupor, tachycardia, tremor, and urinary retention. 

Management: Symptomatic and supportive treatment. Gastric lavage may be done shortly following ingestion.

Storage Condition

Store between 20-25°C. Syrup: Store between 2-8°C.

Alater contains Cetirizine see full prescribing information from innovator Monograph