Alatin is a potent and highly selective antagonist of the peripheral histamine H1-receptor on effector cells in the GI tract, blood vessels and respiratory tract.
Alatin is used for the treatment of seasonal allergic rhinitis and conjunctivitis, perennial allergic rhinitis, pruritus and urticaria. It is also used in allergen induced asthma.
Alatin is also used to associated treatment for these conditions: Chronic Idiopathic Urticaria, Flu caused by Influenza, Perennial Allergic Rhinitis (PAR), Pollen Allergy, Respiratory Allergy, Seasonal Allergic Rhinitis
|Other Names||Cetirizin, Cetirizina, Cetirizine, Cetirizinum|
The mean plasma protein binding of cetirizine is 93% .
|Therapeutic Class||Sedating Anti-histamine|
|Manufacturer||Concord Pharmaceuticals Ltd|
|Last Updated:||June 23, 2021 at 11:18 am|
Table Of contents
- Adults and children over 6 years: 1 tablet (10 mg) once daily or ½ tablet twice daily.
- Children 2-6 years: ½ tablet once daily.
- Adults and children over 6 years: 2 teaspoonful (10 mg) once daily or 1 teaspoon (5 mg) twice daily.
- Children 2-6 years: 1 teaspoonful once daily or ½ teaspoon twice daily.
Alatin dihydrochloride is well tolerated. Lower incidence of sedation, headache, dry mouth, and gastrointestinal disturbances may occur. It does not produce anticholinergic effects.
Caution should be exercised when driving a car or operating a heavy machinery. Concurrent use of cetirizine with alcohol or other CNS depressants should be avoided because additional reduction in alertness and CNS performance may occur.
No clinically significant drug interactions have been found with theophylline, azithromycin, pseudoephedrine, ketoconazole or erythromycin and with some other drugs.
- Avoid alcohol.
- Take with or without food. The absorption is unaffected by food.
Volume of Distribution
Apparent volume of distribution: 0.44 +/- 0.19 L/kg .
Plasma elimination half-life is 8.3 hours .
Apparent total body clearance: approximately 53 mL/min .
Alatin is mainly eliminated by the kidneys , . Dose adjustment is required for patients with moderate to severe renal impairment and in patients on hemodialysis .
Pregnancy & Breastfeeding use
Pregnancy category B. There are no adequate and well controlled studies in pregnant women. Alatin should be used during pregnancy only if clearly needed. Alatin has been reported to be excreted in human breast milk. As large amount of drugs are excreted in human milk, use of Alatin in nursing mother is not recommended.
Alatin Dihydrochloride is contraindicated in those patients with a known hypersensitivity to it or any of its ingredients or hydroxyzine.
Symptoms: Confusion, dizziness, fatigue, headache, malaise, restlessness, sedation, somnolence, diarrhoea, mydriasis, pruritus, stupor, tachycardia, tremor, and urinary retention.
Management: Symptomatic and supportive treatment. Gastric lavage may be done shortly following ingestion.
Store between 20-25°C. Syrup: Store between 2-8°C.