Ala-Hist

Ala-Hist Uses, Dosage, Side Effects, Food Interaction and all others data.

Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.

Ala-Hist is an antihistaminergic medication of the propylamine class. It is a first-generation antihistamine. In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Ala-Hist is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Trade Name Ala-Hist
Availability Rx and/or OTC
Generic Brompheniramine
Brompheniramine Other Names Bromfeniramina, Brompheniramin, Bromphéniramine, Brompheniramine, Brompheniraminum
Related Drugs prednisone, cetirizine, loratadine, fluticasone nasal, promethazine, diphenhydramine, triamcinolone, Benadryl, Zyrtec, chlorpheniramine
Type
Formula C16H19BrN2
Weight Average: 319.239
Monoisotopic: 318.073161265
Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Ala-Hist
Ala-Hist

Uses

Ala-Hist is a histamine H1 antagonist used to treat coughs, upper respiratory symptoms, and nasal congestion associated with allergies and the common cold.

For the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.

Ala-Hist is also used to associated treatment for these conditions: Acute nasopharyngitis, Allergic Rhinitis (AR), Allergies, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Bronchitis, Fever, Flu caused by Influenza, Headache, Pollen Allergy, Rhinorrhoea, Airway secretion clearance therapy

How Ala-Hist works

Ala-Hist is an antagonist of the H1 histamine receptors with moderate antimuscarinic actions, as with other common antihistamines such as diphenhydramine. Due to its anticholindergic effects, brompheniramine may cause drowsiness, sedation, dry mouth, dry throat, blurred vision, and increased heart rate.

Toxicity

Oral, rat: LD50 = 318 mg/kg. Signs of overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.

Food Interaction

  • Avoid alcohol.
  • Take with food.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Elimination Route

Antihistamines are well absorbed from the gastrointestinal tract after oral administration.

Innovators Monograph

You find simplified version here Ala-Hist

http://classyfire.wishartlab.com/tax_nodes/C0000000
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http://classyfire.wishartlab.com/tax_nodes/C0004144
http://classyfire.wishartlab.com/tax_nodes/C0002239
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0001515
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:3183
http://www.hmdb.ca/metabolites/HMDB0001941
http://www.genome.jp/dbget-bin/www_bget?drug:D07543
http://www.genome.jp/dbget-bin/www_bget?cpd:C06857
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6834
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508137
https://www.chemspider.com/Chemical-Structure.6573.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017666
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1767
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=3183
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL811
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001066
http://www.pharmgkb.org/drug/PA448675
https://www.drugs.com/cdi/brompheniramine-12-hour-sustained-release-tablets.html
https://en.wikipedia.org/wiki/Brompheniramine
*** Taking medicines without doctor's advice can cause long-term problems.
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