Ademetionine Uses, Dosage, Side Effects, Food Interaction and all others data.

Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)

S-adenosylmethionine is an intermediate metabolite of methionine. Its involvement in methylation assists in cellular growth and repair, maintains the phospho-bilipid layer in cell membranes. It also helps in the maintenance of the action of several hormones and neurotransmitters that affect mood. Highest concentration are found in the brain and the liver.

Trade Name Ademetionine
Generic Ademetionine
Ademetionine Other Names Ademetionine, AdoMet, L-S-Adenosylmethionine, S-Adenosylmethionine, SAM-e, SAMe
Formula C15H22N6O5S
Weight Average: 398.44
Monoisotopic: 398.137239006
Groups Approved, Investigational, Nutraceutical
Therapeutic Class
Available Country
Last Updated: September 19, 2023 at 7:00 am


S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as a dietary supplement for the support of bone and joint health, as well as mood and emotional well being.

Ademetionine is also used to associated treatment for these conditions: Fatigue, Intrahepatic, Cholestasis, Major Depressive Disorder (MDD)

How Ademetionine works

S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules.


Irritating to mucus membranes and upper respiratory tract. Can cause CNS depression.

Elimination Route

S-Adenosylmethionine is absorbed from the small intestine following oral intake. As absorption is affected by food, it is best to take on an empty stomach. Bioavailability is low following oral intake.

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How safe is Ademetionine?

Ademetionine is used in the treatment of liver disease. It is used in liver condition associated with reduced bile formation. Ademetionine protects the liver cells from toxins and helps the liver to perform its normal function.

How safe is Ademetionine?

Ademetionine is considered safe for most adults. However, it can worsen symptoms in patients with certain disorders, such as bipolar disorder or Parkinson's disease.

What are the common side effects of Ademetionine?

Common side effects of Ademetionine are include:

  • gas
  • constipation
  • diarrhea
  • vomiting
  • dry mouth
  • headache
  • mild insomnia
  • anorexia
  • sweating
  • dizziness
  • nervousness
  • skin rashes
  • serotonin syndrome

Is Ademetionine safe during pregnancy?

Pregnant women should not take Ademetionine.

Is Ademetionine safe during breastfeeding?

Ademetionine is considered safe for most adults.

Can I drink alcohol with Ademetionine?

Avoid consumption of alcohol while taking Ademetionine as it may cause increased dizziness and liver damage.

How do I take Ademetionine?

Ademetionine tablets should be swallowed whole. For better absorption of ademetionine and complete therapeutic effect, ademetionine tablets should not be taken with meals.

How long does Ademetionine take to work?

The effects of IV or IM treatment are evident after 1-2 weeks of therapy, whereas, oral treatment is suitable for maintenance therapy.

What is the common side effects of Ademetionine?

The half-life is about 100 minutes.

Can I take Ademetionine for a long time?

You are advised to take Ademetionine for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as abdominal discomfort, abdominal pain, diarrhea, nausea, dizziness, insomnia.

Can I stop taking Ademetionine?

Do not discontinue Ademetionine without consulting your doctor. To treat your condition effectually, continue taking Ademetionine for as long as prescribed.

Who should not take Ademetionine?

Do not take Ademetionine if you are allergic to any of its contents, if you have used an MAO inhibitor in the past 14 days, inflammation of gall bladder and bile ducts, narrowing or blockage bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer.

What happens if I miss a dose?

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra Ademetionine to make up the missed dose.

Can I overdose on Ademetionine?

Cases of overdose with Ademetionine appear to be rare. Physicians should contact local poison control centers. In general, patients should be monitored and supportive care provided. Known hypersensitivity to ademetionine or to any of the excipients of Heptral.

Can Ademetionine affect my heart?

Side effects can include heart problems, shivering, and anxiety.

Can Ademetionine affects my liver?

Ademetionine can be given to children with caution if prescribed by the doctor. Avoid consuming alcohol along with Ademetionine as it could lead to increased drowsiness and liver damage.

Does Ademetionine cause weight loss?

Ademetionine works more rapidly and does not cause weight gain, sexual dysfunction, sedation, or cognitive interference.

Is Ademetionine safe for kidneys?

The established nephroprotective properties of Ademetionine that are potentiated by Meldonium are probably due to the ability of these Ademetionine to eliminate endothelial dysfunction, improve microcirculation, and prevent the progression of kidney fibrosis.

Does Ademetionine increase dopamine?

Ademetionine increases turnover of serotonin and may increase levels of dopamine and norepinephrine.

*** Taking medicines without doctor's advice can cause long-term problems.