Aculip H

Aculip H Tablet

Chlordiazepoxide: Chlordiazepoxide enhances activity of the inhibitory transmitter GABA in different parts of CNS by increasing neuronal-membrane permeability to chloride ions resulting to hyperpolarisation and stabilisation. It has some muscle relaxant and anticonvulsant activity.

Amitriptyline: Amitriptyline is a dibenzocycloheptadiene tricyclic antidepressant. It increases synaptic concentration of serotonin and/or norepinephrine in the CNS by blocking the neuronal reuptake of norepinephrine and serotonin.

Uses

Depression with Anxiety, agitation or tension.

Aculip H

Trade Name Aculip H
Generic Amitriptyline + Chlordiazepoxide
Weight 5mg
Type Tablet
Therapeutic Class Combined anxiolytics & anti-depressant drugs
Manufacturer Shine Pharmaceuticals Ltd
Available Country India
Last Updated: June 23, 2021 at 9:00 am

Structure

Aculip H
Amitriptyline + Chlordiazepoxide Structure

Dosage

Aculip H dosage

1 tablet (5 mg chlordiazepoxide and 12.5 mg amitriptyline) three to four times daily; may increase to 6 tablets if necessary

Side Effects

Drowsiness, Dry mouth, Constipation, Blurred vision, Dizziness, Bloating, Vivid dreams, Impotence, Tremor, Confusion, Nasal congestion, Edema, Syncope, Ataxia, EEG abnormalities, Menstrual irregularities, Blood dyscrasias (agranulocytosis), Hepatic dysfunction (jaundice).

Precaution

Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults (age <24 yr) taking antidepressants for major depressive disorders and other psychiatric illnesses.

Caution in BPH, urinary/GI retention, increased IOP, thyroid dysfunction, open-angle glaucoma, seizure disorders, brain tumor, respiratory impairment, respiratory disease. Risk of anticholinergic side-effects. May cause orthostatic hypotension. Paradoxical reactions including hyperactive or aggressive behavior reported.

Both agents may cause sedation and impair ability to perform tasks requiring mental alertness. Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; monitor during the initial 1 -2 months of therapy and dosage adjustments.

Not approved for treatment of dementia-related psychosis.

Pregnancy & Breastfeeding use

Pregnancy Category D. There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Lactation: Excretion in milk unknown; not recommended

Contraindication

Hypersensitivity. Severe cardiovascular disorders, Angle clossure glaucoma, Within 14 days of MAOIs, Any drugs or conditions that prolong QT interval, Acute recovery post-MI.

Innovators Monograph

Aculip H contains Amitriptyline + Chlordiazepoxide see full prescribing information from innovator Monograph

FAQ

What is the use of Aculip H?

Aculip H is used to treat mental depression that occurs with anxiety or nervous tension.

How does Aculip H works?

Chlordiazepoxide belongs to a class of drugs called benzodiazepines. Amitriptyline belongs to a class of drugs called tricyclic antidepressants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Amitriptyline/chlordiazepoxide works on your central nervous system. It increases the level of certain chemicals in your brain. This improves your symptoms of depression and anxiety.

What is the side effects of Aculip H?

Aculip H tablet may cause dizziness and drowsiness during the first few hours after you take it. 
More common side effects of Aculip H are

  • drowsiness
  • dry mouth
  • nasal congestion
  • constipation
  • blurred vision
  • dizziness
  • bloating
  • vivid dreams
  • tremors (uncontrollable rhythmic movements in one part of your body)
  • erectile dysfunction (trouble getting or keeping an erection)
  • confusion

Is Aculip H safe during breastfeeding?

There are no adequate studies in women for determining infant risk when taking during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

can I drink alcohol with Aculip H?

The use of drinks that contain alcohol can increase your risk of sedation and drowsiness to dangerous levels from this drug. If you drink alcohol, talk to your doctor.

Is Aculip H safe in pregnancy?

Safe use of Aculip H during pregnancy has not been established. The chlordiazepoxide component of this drug has been shown to increase the risk of negative effects to the fetus. This risk is higher during the first trimester of pregnancy. Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk.