Rexcef Cv

Rexcef Cv Tablet

Cefpodoxime-Clavulanic acid is a combination of two drugs and is effective against multiple infection types. Clavulanic acid component protects degeneration of cefpodoxime in presence of beta-lactamase enzymes and increases the antibiotic spectrum.

Clavulanic acid in cefpodoxime-Clavulanic preparation prevents the resistance to Cefpodoxime that may increase with continuous usage of the drug. It has shown effectiveness against multiple Gram-positive and Gram-negative bacteria and is generally well tolerated.

Uses

URTIs

-Pharyngitis

-Tonsillitis

 

LRTIs

-Acute exacerbations of chronic bronchitis

-Acute community acquired pneumonia

SSTIs

UTIs

-Cystitis

-Uncomplicated urinary tract infections

Enteric fever

General gonorrhea and rectal gonococcal infections.

Rexcef Cv

Trade Name Rexcef Cv
Generic Cefpodoxime + Clavulanic Acid
Type Tablet
Therapeutic Class Third generation Cephalosporins
Manufacturer Signova Pharma Pvt Ltd
Available Country India
Last Updated: June 23, 2021 at 9:00 am

Structure

Rexcef Cv
Cefpodoxime + Clavulanic Acid Structure

Dosage

Rexcef Cv dosage

Pharyngitis or tonsillitis:- (Duo-5 LS) 100 mg 12 hourly for 5 to 10 days

Uncomplicated urinary tract infections: (Duo-5 LS) 100 mg 12 hourly for 7 days

Complicated urinary tract infections: (Duo-5) 200 mg 12 hourly for7 days

Acute community acquired pneumonia: (Duo-5) 200 mg 12 hourly for 14 days

Acute bacterial exacerbations of chronic bronchitis: (Duo-5) 200 mg 12 hourly for 10 days

Uncomplicated gonorrhea and rectal gonococcal infections: (Duo-5) single dose

Skin and skin structure infections: (Duo-5) 200-400 mg 12 hourly for 7 to 14 days

Acute maxillary sinusitis: (Duo-5) 200 mg 12 hourly for 10 days

Enteric fever: (Duo-5) 200 mg 12 hourly for 7 to 14 days

Patients with renal dysfunction: For patients with severe renal impairment (< 30 ml/min creatinine clearance), the dosing intervals should be increased to 24 hourly. In patients maintained on hemodialysis, the dose frequency should be 3 times/week after hemodialysis.

Patients with cirrhosis: Cefpodoxime pharmacokinetics in cirrhotic patients (with or without ascites) is similar to those in healthy subjects. Dose adjustment is not necessary in this population.

Side Effects

It has very few side effects. The side effects include diarrhoea, nausea, skin and vaginal fungal infection, vulvo-vaginal infections, abdominal pain and headache.

Precaution

Cross hypersensitivity in penicillin sensitive patients, leading to serious acute hypersensitivity reactions may need treatment with epinephrine along with other emergency measures such as intravenous fluids, oxygen, airway management and intravenous antihistamine, as clinically indicated.

Interaction

Probenecid: Renal excretion of Cefpodoxime proxetil was inhibited by Probenecid and resulted in an approximately 31% increase in AUC.

Nephrotoxic drugs: Close monitoring of renal function is advised when Cefpodoxime proxetil is administered concomitantly with compounds of known nephrotoxic potential.

Pregnancy & Breastfeeding use

Pregnancy

Cefpodoxime is pregnancy category B. And Clavulanic acid is pregnancy category B.

Contraindication

It is contraindicated in patients with a known allergy to cefpodoxime and clavulanic acid or to the cephalosporin group of antibiotics.

Special Warning

Patients with renal dysfunction: For patients with severe renal impairment (< 30 ml/min creatinine clearance), the dosing intervals should be increased to 24 hourly. In patients maintained on hemodialysis, the dose frequency should be 3 times/week after hemodialysis.

Patients with cirrhosis: Cefpodoxime pharmacokinetics in cirrhotic patients (with or without ascites) is similar to those in healthy subjects. Dose adjustment is not necessary in this population.

Interaction with other Medicine

Probenecid: Renal excretion of Cefpodoxime proxetil was inhibited by Probenecid and resulted in an approximately 31% increase in AUC.

Nephrotoxic drugs: Close monitoring of renal function is advised when Cefpodoxime proxetil is administered concomitantly with compounds of known nephrotoxic potential.

Storage Condition

Store in cool and dry place. Keep away from children.