Sinusoidal Obstruction Syndrome (SOS)

Sinusoidal Obstruction Syndrome (SOS)

Sinusoidal Obstruction Syndrome (SOS) is a medical condition characterized by partial obstruction of the hepatic sinusoids, leading to sinusoidal congestion and organ dysfunction. It can be caused by a variety of etiologies, including cancer chemotherapy, direct infiltration of tumor cells, radiation, and iron overload. Patents with SOS may present with a variety of symptoms, depending on the severity of the underlying obstruction.


Patients with SOS typically present with fatigue, abdominal pain, jaundice, hepatomegaly, tenderness to palpation, thrombocytopenia, and ascites. Other signs and symptoms associated with SOS may include pleural effusion, variceal bleeding, hepatic encephalopathy, and renal dysfunction.


Sinusoidal Obstruction Syndrome is typically diagnosed with imaging tests such as ultrasound, CT scan, or MRI. However, liver biopsy may also be of some value in helping to differentiate SOS from other causes of liver disease, such as cirrhosis.


The primary treatment approach for Sinusoidal Obstruction Syndrome is to address the underlying cause of the obstruction. Depending on the cause, treatment may involve the use of chemotherapy, radiation therapy, or other medical interventions. Additionally, supportive care to help alleviate symptoms may include:

  • Medications to reduce symptoms such as pain and jaundice
  • Dietary therapy to reduce the strain on the liver
  • Supplementation with vitamins and antioxidants
  • Surgical interventions in more serious cases

It is important to note that Sinusoidal Obstruction Syndrome can be a life-threatening condition if not treated promptly. Therefore, it is important to seek prompt medical attention if you experience any of the signs or symptoms associated with SOS.