Metastatic Endometrial carcinoma

Metastatic Endometrial Carcinoma

Metastatic endometrial carcinoma is a type of cancer that begins in the endometrium, the lining of the uterus. The cancerous cells spread to surrounding organs or distant sites very quickly, and can be difficult to treat. Metastatic endometrial carcinoma can cause painful symptoms and can be life-threatening. It is the most common type of gynecologic cancer in Americans.

Endometrial carcinomas are divided into two main categories: non-metastatic and metastatic. Metastatic endometrial cancer cells have the ability to invade and colonize other organs in the body. This is the most advanced stage of endometrial cancer, and it is typically difficult to treat.

Symptoms of metastatic endometrial carcinoma may vary depending on the type and location of the tumor. Most common symptoms may include:

  • Abnormal vaginal bleeding
  • Pain in the pelvic area
  • Pain during intercourse
  • Frequent urination
  • Loss of appetite
  • Fatigue
  • Weight loss

If you experience any of these symptoms, it's important to see a doctor. Your doctor will perform a physical exam, request a biopsy, and order imaging tests such as an X-ray or ultrasound, CT scan, or MRI to confirm a diagnosis of metastatic endometrial carcinoma.

Treatment for metastatic endometrial carcinoma can include surgery, chemotherapy, radiation therapy, and targeted therapy. In most cases, a combination of therapies is recommended.

Surgery is usually the first step in treating metastatic endometrial cancer. Depending on the stage and location of the cancer, your doctor may recommend a hysterectomy (removal of the uterus), lymph node removal, pelvic exenteration, or a combination of these procedures.

Chemotherapy is usually recommended in addition to or after surgery, and is used to reduce the size of the tumor or to kill any remaining cancer cells. Oral or intravenous chemotherapy drugs are commonly used. Radiation therapy is also used to target areas of the body where the cancer has spread, including the lymph nodes. Targeted therapy may be used as well, which helps target and kill cancer cells without damaging healthy cells.

Metastatic endometrial carcinoma can be difficult to treat, and it is important to seek medical attention as soon as you experience any of the symptoms. With early diagnosis and treatment, the prognosis for this type of cancer is much improved.