Advanced Mismatch Repair-deficient (dMMR) Endometrial Cancer
What is Advanced Mismatch Repair-deficient (dMMR) Endometrial Cancer?
Advanced Mismatch Repair-deficient (dMMR) Endometrial Cancer is a type of endometrial cancer which results from a mutation in the mismatch repair gene (MMR) gene. This mutation leads to a damaged mismatch repair protein, which results in cancerous cells. These cells have a greater chance of forming and growing quickly, which can lead to a more aggressive form of cancer.
MMR-Deficient Endometrial Cancer is more common in women over the age of 60. It is also more likely to be diagnosed in women who have had a hysterectomy or prior endometrial ablation.
Signs and Symptoms of Advanced Mismatch Repair-Deficient Endometrial Cancer
The signs and symptoms of advanced Mismatch Repair-Deficient Endometrial Cancer can vary depending on the stage and location of the cancer. Common signs and symptoms include:
- Unusual vaginal bleeding or discharge
- Pelvic pain or pressure
- Pain during sex
- Pain while urinating or when having a bowel movement
- Loss of appetite
- Weight loss
- Fatigue
Treatments for Advanced Mismatch Repair-Deficient Endometrial Cancer
Treatment for Advanced Mismatch Repair-Deficient Endometrial Cancer typically includes a combination of surgery, radiation therapy, and/or chemotherapy. The type of treatment chosen depends upon the stage and location of the cancer. Surgery to remove the tumor is usually recommended for early-stage cancers. Radiation therapy and/or chemotherapy may be recommended for more advanced cancers.
In some cases, clinical trials may be an option for patients with Advanced Mismatch Repair-Deficient Endometrial Cancer. Clinical trials are research studies that test new treatments and share results with the medical community. Patients interested in participating in a clinical trial should talk to their medical team for more information.