Zehist

Zehist Uses, Dosage, Side Effects, Food Interaction and all others data.

Zehist, a non-sedating antihistamine, blocks histamine H1-receptors on effector cells of the GI tract, blood vessels and respiratory tract. It also has mast-cell stabilising properties.

Trade Name Zehist
Generic Mizolastine
Mizolastine Other Names Mizolastina, Mizolastine, Mizolastinum
Type Tablet
Formula C24H25FN6O
Weight Average: 432.503
Monoisotopic: 432.207387612
Groups Approved, Investigational
Therapeutic Class Non-sedating antihistamines
Manufacturer Lupin
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Zehist
Zehist

Uses

Zehist is used for the symptomatic relief of the following conditions:

  • Seasonal allergic rhinoconjunctivitis (hay fever)
  • Perennial allergic rhinoconjunctivitis
  • Urticaria

Zehist is also used to associated treatment for these conditions: Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis, Urticaria

Dosage

Zehist dosage

Adult and children above 12 years: The usual recommended dose is one 10 mg tablet daily.

Children below 12 years: Not recommended.

Side Effects

Zehist is well tolerated in the recommended doses. The usual side effects are dry mouth, diarrhoea, abdominal pain, nausea, drowsiness, headache, dizziness, raised liver enzymes, hypotension, tachycardia and palpitations. Bronchospasm and aggravation of asthma were reported, but in view of the high frequency of asthma in the treated patient population, a causality relationship remains uncertain.

Precaution

Patients should be warned that a small number of individuals may experience sedation. It is therefore advisable to determine individual response before driving or performing complicated task.

Interaction

Systemically administered Ketoconazole and Erythromycin, antiarrythmics e.g. Amiodarone moderately increase the plasma concentration of Zehist. This could increase the risk of arrythmias. Concurrent use of other potent inhibitor of the cytochrome P 450 3A4 enzyme e.g. Ciclosporin should be approached with caution. No potentiation of the sedation and the alteration in performance caused by alcohol with Zehist has been observed.

Pregnancy & Breastfeeding use

The safety of Zehist for use in human pregnancy has not been established. The evaluation of experimental animal studies does not indicate direct or indirect harmful effects with respect to the development of the embryo or foetus, the course of gestation and peri and post-natal development. Zehist should be avoided in pregnancy (particularly the 1 st trimester). Zehist is excreted into breast milk, therefore it is not recommended during lactation.

Contraindication

Zehist is contra-indicated in patients with clinically significant cardiac disease or a history of symptomatic arrhythmias and in patients with known or suspected QT prolongation, patients with electrolyte imbalance (particularly hypokalaemia), and in those with clinically significant bradycardia. It is also contra-indicated in patients taking other drugs that decrease its metabolism, patients with significantly impaired liver function, and in patients who are hypersensitive to the drug.

Acute Overdose

In cases of overdosage, general symptomatic surveillance with cardiac monitoring including QT interval and cardiac rhythm for at least 24 hours is recommended, along with standard measures to remove any unabsorbed drug. Studies in patients with renal insufficiency suggest that haemodialysis does not increase clearance of the drug.

Storage Condition

Store in a cool & dry place. Protect from light. It should be kept out of the reach of children.

Innovators Monograph

You find simplified version here Zehist

*** Taking medicines without doctor's advice can cause long-term problems.
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