Ya Jie

Ya Jie Uses, Dosage, Side Effects, Food Interaction and all others data.

Ya Jie is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.

Ya Jie
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Ya Jie
Generic	Ornidazole
Ornidazole Other Names	ornidazol, Ornidazole
Type
Formula	C₇H₁₀ClN₃O₃
Weight	Average: 219.63 Monoisotopic: 219.0410689
Groups	Investigational
Therapeutic Class	Amoebicides, Anti-diarrhoeal Antiprotozoal
Manufacturer
Available Country	China
Last Updated:	September 19, 2023 at 7:00 am

Uses

Ya Jie is used for Amoebiasis (Intestinal and hepatic), Giardiasis, Trichomoniasis, Bacterial vaginosis, Treatment of susceptible anaerobic infections

Ya Jie is also used to associated treatment for these conditions: Amebiasis, Anaerobic Bacterial Infection, Chlamydial Infections, Gastrointestinal Infections caused by entamoeba histolytica, Giardiasis, Mixed Vaginal Infections, Surgical Site Infections, Trichomonal Vaginitis, Trichomoniasis

Dosage

Ya Jie dosage

Amoebiasis:

Adults: 500 mg twice a day for 5 days.
Children: 10-25 mg per kg body weight in two divided doses.

Amoebic dysentery:

Adults: 1.5 gm once a day for 3 days.
Children: 40 mg per kg body weight, once a day for 3 days.

Giardiasis:

Adults: 1.5 gm once daily for 1-2 days.
Children: 40 mg per kg body weight for 2 days.

Trichomoniasis: 1.5 gm once or 500 mg twice a day for 5 days. Sexual partner should also be treated at the same time.

Bacterial vaginosis: 3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days.

Side Effects

Side effects of Ya Jie have been mainly limited to the gastrointestinal tract (nausea, vomiting, epigastric pain) and central nervous system (dizziness, headache, lassitude). Unlike other nitroimidazoles, Ya Jie does not interact with alcohol, although this requires further study.

Leukopenia has been described occasionally during therapy. Adverse central nervous system (CNS) effects of Ya Jie have mainly included headache, dizziness, lassitude or somnolence, fatigue and weakness. Adverse CNS effects of Ya Jie may be less than that happens with metronidazole. Seizures have not been reported with Ya Jie in studies available to date.

Precaution

In patient with ataxia, vertigo, and mental confusion, Ya Jie should be prescribed with caution. During prolonged treatment with Ya Jie, blood dyscrasia namely mild leukopenia have been reported rarely. In case leukopenia occurs, the decision to discontinue the therapy should depend upon the gravity of infection.

Interaction

Like other imidazoles, Ya Jie has a mild potential to cause disulfiramlike reactions. Concomitant administration of oral anticoagulants may increase the risk of haemorrhage due to diminished hepatic metabolism. Ya Jie has been reported to decrease the clearance of 5-fluorouracil.

Pregnancy & Breastfeeding use

Adequate clinical trials have not been conducted. Ya Jie should be prescribed only if the potential benefit justifies the potential risk to fetus/neonate.

Contraindication

Previous hypersensitivity to Ya Jie and to other nitroimidazoles. Ya Jie is contraindicated in central nervous system disorders, particularly in epilepsy or in peripheral neuropathy.