Utodin

Utodin Uses, Dosage, Side Effects, Food Interaction and all others data.

A selective β2-adrenoceptor agonist with its main action on the uterus, causing relaxation. It reduces the intensity and frequency of contractions. Heart rate is also increased while diastolic pressure is reduced. May cause bronchial relaxation but this is not clinically significant in its usage.

Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Utodin is beta-2 adrenergic agonist. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions.

Trade Name Utodin
Availability Discontinued
Generic Ritodrine
Ritodrine Other Names Ritodrina, Ritodrine, Ritodrinium
Related Drugs nifedipine, progesterone, terbutaline, Prometrium, Crinone
Type Injection, Tablet
Formula C17H21NO3
Weight Average: 287.3535
Monoisotopic: 287.152143543
Protein binding

~56%

Groups Approved, Investigational
Therapeutic Class Drugs acting on the Uterus
Manufacturer Ranbaxy Laboratories (sun Pharma), Sun Pharma
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Utodin
Utodin

Uses

Utodin is used for the treatment of uncomplicated premature labour

Utodin is also used to associated treatment for these conditions: Foetal distress syndrome, Premature Births, Premature Labour, Uterine Contractions

How Utodin works

Utodin is beta-2 adrenergic agonist. It binds to beta-2 adrenergic receptors on outer membrane of myometrial cell, activates adenyl cyclase to increase the level of cAMP which decreases intracellular calcium and leads to a decrease of uterine contractions.

Dosage

Utodin dosage

By intravenous infusion: Initially 50 mcg/minute, increased gradually according to response by 50 mcg/minute every 10 minutes until contractions stop or maternal heart rate reaches 140 beats/minute; continue for 12–48 hours after contractions cease (usual rate 150–350 mcg/minute); maximum rate 350 mcg/minute.

Intramuscular injection: 10 mg in every 3–8 hours continued for 12–48 hours after contractions have ceased; then by mouth.

Oral maintenance treatment: One tablet (10 mg) may be given approximately 30 minutes before termination of intravenous therapy, repeated every 2 hours for 24 hours, followed by 10–20 mg every 4–6 hours, maximum oral dose 120 mg daily

Side Effects

The common side-effects of ritodrine hydrochloride are nausea, vomiting, flushing, sweating, tremor, hypokalaemia, tachycardia, palpitations, hypotension (left lateral position throughout infusion to minimize risk), uterine bleeding, pulmonary oedema; chest pain or tightness, arrhythmias and salivary gland enlargement. On prolonged administration for several weeks may cause leucopenia and agranulocytosis; liver function abnormalities including increased transaminases and hepatitis.

Toxicity

LD50=64mg/kg (mice, IV); LD50=540 mg/kg (mice, oral); LD50=85 mg/kg (rat, IV)

Precaution

It should be used cautiously in patient with suspected cardiac diseases, hypertension, hyperthyroidism, hypokalaemia, diabetes mellitus, mild to moderate preeclampsia, monitor blood pressure and pulse rate and avoid over-hydration during taking ritodrine hydrochloride.

Interaction

Increased risk of hypokalamia if high doses of corticosteroids, diuretics (acetazalamide, loop diuretics and thiazides) or theophylline given with high doses of ritodrine. A sufficient time interval should elapse prior to administration of another sympathomimetic drug. β–adrenergic blocking drugs inhibit its action; coadministraton of these drugs should, therefore, be avoided. With anesthetics used in surgery, the possibility that hypotensive effects may be potentiated should be considered.

Food Interaction

No interactions found.

Half Life

1.7-2.6 hours

Pregnancy & Breastfeeding use

Utodin is a drug of pregnancy category B. There are no adequate and well controlled studies of effects in pregnant women before 20 weeks gestation; therefore, this drug should not be used before the 20th week of pregnancy. Studies in pregnant women from the 20th week of gestation onwards have not shown increased risk of fetal abnormalities. Nonetheless, although clinical studies did not indicate a risk of permanent adverse fetal effects from ritodrine, the possibility cannot be excluded; therefore, it should be used only when clearly indicated. In frequently reported neonatal symptoms include hypoglycemia and ileus. In addition, hypocalcemia and hypotension have been reported in neonates whose mothers were treated with other beta mimetic agents. Caution should be exercised unless the potential benefit of treatment to the mother outweighs any possible risk of the infants.

Contraindication

It is contraindicated in patients with known hypersensitivity to the active ingredient or any of the excipients of this component. β2-agonists are contra-indicated in cardiac disease and in patients with significant risk factors for myocardial ischaemia; they should also be avoided in antepartum haemorrhage, intra-uterine infection, intra-uterine fetal death, placenta praevia, abruptio placenta, threatened miscarriage, cord compression, and eclampsia or severe preeclampsia.

Acute Overdose

Symptoms of overdosage are tachycardia (maternal and fetal), palpitation, cardiac arrhythmia, hypotension, nervousness, tremor, nausea and vomiting. If an excess of ritodrine tablets is ingested, gastric lavage or induction of emesis should be carried out followed by administration of activated charcoal. When symptoms of overdose occur as a result of parenteral administration, ritodrine should be discontinued; an appropriate β-blocking agent may be usedas an antidote.

Storage Condition

Keep away from the reach of the children. Store in cool & dry place protected from light

Innovators Monograph

You find simplified version here Utodin

FAQ

What is Utodin used for?

Utodin is used to stop premature labor. This medicine was available only with your doctor's prescription.

How safe is Utodin?

The use of Utodin during pregnancy is generally associated with higher hazard of autism, even after adjusting confounders such as maternal age, neonatal birth weight, preterm birth, preterm labor and steroid use.

How does Utodin work?

Utodin working by decreases intracellular calcium concentration.The Utodin decrease of calcium concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions.

What are the common side effects of Utodin?

Common side effects of Utodin are include:

  • Blurred vision
  • chest pain or tightness
  • dizziness or lightheadedness
  • drowsiness
  • dry mouth
  • fast or irregular heartbeat—rare with oral form
  • flushed and dry skin
  • fruit-like breath odor
  • increased urination
  • loss of appetite
  • nausea
  • severe pounding or racing heartbeat—rare with oral form
  • shortness of breath—rare with oral form
  • sleepiness
  • stomachache
  • tiredness
  • troubled breathing (rapid and deep)
  • unusual thirst
  • vomiting

Is Utodin safe during pregnancy?

There are no controlled data in human pregnancy. Neonatal hypoglycemia, tachycardia, and ileus have been reported. Rarely, ketoacidosis resulting in fetal death has been reported. Utodin is only recommended for use during pregnancy when benefit outweighs risk.

Is Utodin safe during breastfeeding?

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

When should be best taken of Utodin?

first twenty-four hours after the doctor stops your intravenous Utodin, your dose may be as high as 10 milligrams (mg) every two hours. After that, the dose is usually 10 to 20 mg every four to six hours.

How often can I take Utodin?

Utodin is usually 40 mg every eight to twelve hours.

Can I drink alcohol with Utodin?

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Can Utodin effects my heart?

Utodin should be used with caution if you have heart problems as this medicine may increase the risk of irregular heartbeat and alters your blood pressure. Your doctor may suggest tests to monitor your electrolyte levels and the functioning of your heart.

What happens if I miss a dose?

If you miss a dose of Utodin, take the missed dose as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Can I overdose on Utodin?

Never take more than the prescribed dose. Seek emergency medical treatment in case of a suspected overdose of Utodin.

What is the mechanism of action of Utodin?

The effect of Utodin can be observed within 5 minutes when administered intravenously. It is not known when this medicine starts its action after oral administration.

What is the effect of Utodin on the Liver?

Utodin is not harmful for the liver.

What is the effect of Utodin on the Kidneys?

Utodin is completely safe for kidney.

Does Utodin cause hyperglycemia?

Utodin the main traditional drug in Japan, is a beta-2 stimulant that causes maternal hyperglycemia.

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*** Taking medicines without doctor's advice can cause long-term problems.
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