Transfer

Transfer Uses, Dosage, Side Effects, Food Interaction and all others data.

Transfer regulates erythropoiesis by stimulating the differentiation and proliferation of erythroid precursors, stimulating the release of reticulocytes into the circulation, and synthesis of cellular haemoglobin. Recombinant human erythropoietin is available as epoetin alfa and epoetin beta which are used in the management of anaemias associated with CRF, cancer chemotherapy and anti-AIDS drug zidovudine.

Transfer and epoetin alfa are involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. It is reported to increase the reticulocyte count within 10 days of initiation, followed by increases in the RBC count, hemoglobin, and hematocrit, usually within 2 to 6 weeks . Depending on the dose administered, the rate of hemoglobin increase may vary. In patients receiving hemodialysis, a greater biologic response is not observed at doses exceeding 300 Units/kg 3 times weekly .

Epoetin alfa serves to restore erythropoietin deficiency in pathological and other clinical conditions where normal production of erythropoietin is impaired or compromised. In anemic patients with chronic renal failure (CRF), administration with epoetin alfa stimulated erythropoiesis by increasing the reticulocyte count within 10 days, followed by increases in the red cell count, hemoglobin, and hematocrit, usually within 2 to 6 weeks . Epoetin alfa was shown to be effective in increasing hematocrit in zidovudine-treated HIV-infected patients and anemic cancer patients undergoing chemotherapy .

Trade Name Transfer
Generic Erythropoietin
Erythropoietin Other Names E.P.O., Epoetin alfa, Epoetin alfa rDNA, Epoetin alfa-epbx, Epoetin alfa, recombinant, Epoetin beta, Epoetin beta rDNA, Epoetin epsilon, Epoetin gamma, Epoetin gamma rDNA, Epoetin kappa, Epoetin omega, Epoetin theta, Epoetin zeta, Epoetina alfa, Epoetina beta, Epoetina dseta, Epoetina zeta, Epoétine zêta, Epoetinum zeta, Erythropoiesis stimulating factor, Erythropoietin (human, recombinant), Erythropoietin (recombinant human), ESF, SH-polypeptide-72
Type Pfs Injection, Injection, Pre Filled Syringe Of Solution For Injection, Pre Filled Syringe Injection
Formula C815H1317N233O241S5
Weight 18396.1 Da
Protein binding

No information of serum protein binding available.

Groups Approved
Therapeutic Class Drugs for Haemolytic Hypoplastic & Renal Anemia
Manufacturer Alniche Life Sciences Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Transfer
Transfer

Uses

Anaemia in zidovudine-treated HIV-infected patients, Anaemia of chronic renal failure, Anaemia of prematurity, Anaemia related to non-myeloid malignant disease chemotherapy, To reduce the need for allogenic blood tranfusion.

Transfer is also used to associated treatment for these conditions: Anemia, Anemia caused by Zidovudine, Reduction of allogeneic RBC transfusions in patients undergoing elective, noncardiac, nonvascular surgery

How Transfer works

Transfer or exogenous epoetin alfa binds to the erythropoietin receptor (EPO-R) and activates intracellular signal transduction pathways . The affinity (Kd) of EPO for its receptor on human cells is ∼100 to 200 pM . Upon binding to EPO-R on the surface of erythroid progenitor cells, a conformational change is induced which brings EPO-R-associated Janus family tyrosine protein kinase 2 (JAK2) molecules into close proximity. JAK2 molecules are subsequently activated via phosphorylation, then phosphorylate tyrosine residues in the cytoplasmic domain of the EPO-R that serve as docking sites for Src homology 2-domain-containing intracellular signaling proteins . The signalling proteins include STAT5 that once phosphorylated by JAK2, dissociates from the EPO-R, dimerizes, and translocates to the nucleus where they serve as transcription factors to activate target genes involved in cell division or differentiation, including the apoptosis inhibitor Bcl-x . The inhibition of apoptosis by the EPO-activated JAK2/STAT5/Bcl-x pathway is critical in erythroid differentiation. Via JAK2-mediated tyrosine phosphorylation, erythropoietin and epoetin alfa also activates other intracellular proteins involved in erythroid cell proliferation and survival, such as Shc , phosphatidylinositol 3-kinase (PI3K), and phospholipase C-γ1 .

Dosage

Transfer dosage

Increase yield of autologous blood As epoetin alfa or zeta: 600 IU/kg twice wkly for 3 wk before surgery.Anaemia of chronic renal failure As epoetin alfa

  • Predialysis and haemodialysis: Initial: 50 IU/kg 3 times/wk;
  • Peritoneal dialysis: 50 IU/kg twice wkly.

Anaemia in zidovudine-treated HIV-infected patients As epoetin alfa: Initial: 100 IU/kg 3 times/wk for 8 wk. Max: 300 IU/kg 3 times/wk.

Anaemia related to non-myeloid malignant disease chemotherapy As epoetin alfa or zeta: Initial: 150 IU/kg 3 times/wk, up to 300 IU/kg 3 times/wk.

Anaemia of chronic renal failure:

  • Child: As epoetin alfa: Initially, 50 IU/kg 3 times wkly. May increase dose at 4 wkly intervals in increments of 25 IU/kg 3 times wkly until a target haemoglobin concentration of 9.5-11 g/100 mL is reached. Usual maintenance dose: 30 kg: 90-300 IU/kg/wk.

Side Effects

Hypertension, myalgia, arthralgia, flu-like syndrome, rashes and urticaria. Potentially Fatal: Hypertensive crisis with encephalopathy-like symptoms e.g. headache, confusion, generalised seizures. Thrombosis.

Toxicity

Overdose from epoetin alfa include signs and symptoms associated with an excessive and/or rapid increase in hemoglobin concentration, including cardiovascular events. Patients with suspected or known overdose should be monitored closely for cardiovascular events and hematologic abnormalities. Polycythemia should be managed acutely with phlebotomy, as clinically indicated. Following resolution of the overdose, reintroduction of epoetin alfa therapy should be accompanied by close monitoring for evidence of rapid increases in hemoglobin concentration (>1 gm/dL per 14 days). In patients with an excessive hematopoietic response, reduce the dose in accordance with the recommendations described in the drug label .

Precaution

Chronic renal failure, ischaemic heart diseases, hypertension, pregnancy, seizures, liver dysfunction, lactation.

Interaction

Haematinics enhance efficiency. Increased dose of heparin in patients undergoing dialysis.

Food Interaction

  • Administer iron supplement. When initiating an erythropoiesis-stimulating agent, evaluate iron stores and start iron supplementation if indicated. Most patients with chronic kidney disease require iron supplementation while taking an erythropoiesis-stimulating agent.

Volume of Distribution

In healthy volunteers, the volume of distribution of intravenous epoetin alfa was generally similar to the plasma volume (range of 40–63.80 mL/kg), indicating limited extravascular distribution .

Elimination Route

The time to reach peak concentration is slower via the subcutaneous route than the intravenous route which ranges from 20 to 25 hours, and the peak is always well below the peak achieved using the intravenous route (5–10% of those seen with IV administration) . The bioavailability of subcutaneous injectable erythropoietin is much lower than that of the intravenously administered product and is approximately 20-40% .

Adult and paediatric patients with CRF: Following subcutaneous administration, the peak plasma levels are achieved within 5 to 24 hours .

Cancer patients receiving cyclic chemotherapy: The average time to reach peak plasma concentration was approximately 13.3 ± 12.4 hours after 150 Units/kg three times per week (TIW) subcutaneous (SC) dosing. The Cmax is expected be 3- to 7- fold higher and the Tmax is expected to be 2- to 3-fold longer in patients receiving a 40,000 Units SC weekly dosing regimen .

Half Life

Healthy volunteers: The half life is approximately 4 hours in healthy volunteers receiving an intravenous injection . A half-life of approximately 6 hours has been reported in children .

Adult and paediatric patients with CRF: The elimination half life following intravenous administration ranges from 4 to 13 hours, which is about 20% longer in CRF patients than that in healthy subjects. The half life is reported to be similar between adult patients receiving or not receiving dialysis .

Cancer patients receiving cyclic chemotherapy: Following subcutaneous administration, the average half life is 40 hours with range of 16 to 67 hours .

Clearance

*Healthy volunteers: * In male volunteers receiving intravenous epoetin alfa, the total body clearance was approximately 8.12 ± 1.00 mL/h/kg .

Cancer patients receiving cyclic chemotherapy: The average clearance was approximately 20.2 ± 15.9 mL/h/kg after 150 Units/kg three times per week (TIW) subcutaneous (SC) dosing . The patients receiving a 40,000 Units SC weekly dosing regimen display a lower clearance (9.2 ± 4.7 mL/h/kg) .

Elimination Route

Transfer and epoetin alfa are cleared via uptake and degradation via the EPO-R-expressing cells, and may also involve other cellular pathways in the interstitium, probably via cells in the reticuloendothelial scavenging pathway or lymphatic system . Only a small amount of unchanged epoetin alfa is found in the urine .

Pregnancy & Breastfeeding use

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Contraindication

Uncontrolled hypertension, hypersensitivity to mammalian cell products and human albumin.

Storage Condition

Refrigerate at 2-8° C. Do not freeze.

Innovators Monograph

You find simplified version here Transfer

FAQ

What is Transfer used for?

Transfer is produced by the kidney and used to make red blood cells. Transfer-stimulating agents are used often for people with long-term kidney disease and anemia.

How safe is Transfer?

Transfer is generally considered safe for most people to use short term. The safety of long-term use hasn't been determined. Keep in mind supplements aren't monitored for quality by the Food and Drug Administration.

How does Transfer work?

Transfer acts on red blood cells to protect them against destruction.

What are the common side effects of Transfer?

Common side effects of Transfer are include:

  • Allergic reaction. Rarely, some people have an allergic reaction to erythropoietin. ...
  • Feeling sick or being sick. You may feel sick during treatment with erythropoietin. ...
  • Diarrhoea
  • Blood clot risk
  • Headaches
  • High blood pressure
  • Muscle, joint or bone pain
  • Flu-like symptoms.

Is Transfer safe during pregnancy?

Transfer is a safe therapy that can be used in pregnancy.

Is Transfer safe during breastfeeding?

In small studies,Transfer administration decreased serum prolactin in patients with amyotrophic lateral sclerosis, but had no effect in normal subjects or in patients with renal failure undergoing chronic ambulatory peritoneal dialysis. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

When should Transfer be given?

Transfer are usually given to patients who have chronic  kidney disease or end-stage renal (kidney) disease. These patients usually have lower hemoglobin levels because they can't produce enough Transfer. Transfer are also prescribed for patients who have cancer.

How do Transfer take Transfer?

It is usually given into the thigh or tummy. A nurse can teach you, or a person caring for you, how to inject it. If you or a carer cannot give the injections, a district or practice nurse may do it for you.

How long does Transfer take Transfer to work?

It will take time for Transfer medication to work in your body. Most people take 1 to 2 months to feel better.

How often is Transfer given?

The starting dose is 50 to 100 units per kilogram (kg) injected into a vein or under the skin three times a week.

How long does Transfer stay in my system?

Transfer is undetectable in urine after 3–4 days of injection.

How much Transfer can I take daily?

The recommended Transfer regimens are: 300 Units/kg per day subcutaneously for 15 days total: administered daily for 10 days before surgery, on the day of surgery, and for 4 days after surgery. 600 Units/kg subcutaneously in 4 doses administered 21, 14, and 7 days before surgery and on the day of surgery.

Who should not take Transfer?

You should not use this medication if you are allergic to Transfer, or if: you have untreated ,uncontrolled high blood pressure; you have had pure red cell aplasia (PRCA, a type of anemia) after using darbepoetin alfa or epoetin alfa; you use an epoetin alfa multi-dose vial and you are pregnant or breastfeeding.

When can I stop taking Transfer?

Treatment with epoetin alfa injection products should be stopped when your course of chemotherapy ends.

What happens if I overdose?

Excess Transfer results from chronic exposure to low oxygen levels or from rare tumours that produce high levels of Transfer. It causes a condition known as polycythaemia which means high red blood cell count.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of Transfer.

Can Transfer affects my heart ?

Transfer may have a direct positive effect on the heart and brain unrelated to correction of the anemia by reducing cell apoptosis and by increasing neovascularization, both of which could prevent tissue damage.

Can Transfer affect my kidneys?

When you have kidney disease, your kidneys cannot make enough Transfer. Low Transfer levels cause your red blood cell count to drop and anemia to develop. Most people with kidney disease will develop anemia.

Does Transfer affect liver?

Transfer is produced in the liver during fetal life, but the main production shifts to the kidney after birth. The liver maintains a production capacity of up to 10% of the total Transfer synthesis in healthy controls, but can be up-regulated to 90-100%.

How does kidney make Transfer?

Transfer is a hormone that is produced predominantly by specialised cells called interstitial cells in the kidney.

How often can Transfer be given?

This Transfer is given as an injection under the skin or into a vein as directed by your doctor, usually 1 to 3 times a week.

*** Taking medicines without doctor's advice can cause long-term problems.
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