Titan

Titan Uses, Dosage, Side Effects, Food Interaction and all others data.

Titan is a sterile, semisynthetic, broad-spectrum, 3rd generation cephalosporin antibiotic for intravenous or intramuscular administration. The bactericidal activity of Titan results from inhibition of cell wall synthesis. Titan has a high degree of stability in the presence of beta-lactamases both penicillinases and cephalosporinases of gram-negative and gram- positive bacteria.

Titan is a cephalosporin/cephamycin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Titan has in vitro activity against gram-positive aerobic, gram-negative aerobic, and anaerobic bacteria. The bactericidal activity of ceftriaxone results from the inhibition of cell wall synthesis and is mediated through ceftriaxone binding to penicillin-binding proteins (PBPs). Titan is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended-spectrum beta-lactamases. However, resistance to ceftriaxone usually occurs through beta-lactamase hydrolysis, altered PBPs, or reduced bacterial cell permeability. Titan should not be mixed with or giving in the same IV line as diluents/products containing calcium as they may cause ceftriaxone to precipitate. Titan use may also cause biliary sludge or gallbladder pseudolithiasis.

Trade Name Titan
Availability Prescription only
Generic Ceftriaxone
Ceftriaxone Other Names Ceftriaxona, Ceftriaxone, Ceftriaxonum, Rocephin
Related Drugs amoxicillin, doxycycline, diclofenac ophthalmic, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, dexamethasone ophthalmic, levofloxacin
Weight 250mg, 500mg, 1g, 18mcg, 150mg
Type Injection, Inhalation Capsule, Tablet
Formula C18H18N8O7S3
Weight Average: 554.58
Monoisotopic: 554.04605704
Protein binding

Ceftriaxone is 95% protein bound.

Groups Approved
Therapeutic Class Third generation Cephalosporins
Manufacturer Macter International (pvt) Ltd, , Healthcare Pharmacuticals Ltd, Hexpharm Jaya
Available Country Pakistan, Bangladesh, Indonesia
Last Updated: September 19, 2023 at 7:00 am
Titan
Titan

Uses

Titan is used for the treatment of the following infections when caused by susceptible organisms:

Lower Respiratory Tract Infections caused by Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, E. coli, Enterobacter aerogenes, Proteus mirabilis, Serratia marcescens.

Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase producing strains), Moraxella catarrhalis (including beta-lactamase producing strains).

Skin and Skin Structure Infections caused by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Viridans group streptococci, E. coli, Enterobacter cloacae, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Morganella morganii, Pseudomonas aeruginosa, Serratia marcescens, Acinetobacter calcoaceticus, Bacteroides fragilis, Peptostreptococcus species.

Urinary Tract Infections (complicated and uncomplicated) caused by E. coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Klebsiella pneumoniae.

Uncomplicated Gonorrhea (cervical, urethral, pharyngial and rectal) caused by Neisseria gonorrhoeae, including both penicillinase- and nonpenicillinase-producing strains, and pharyngeal gonorrhea caused by nonpenicillinase-producing strains of Neisseria gonorrhoeae.

Pelvic Inflammatory Disease caused by Neisseria gonorrhoeae.

Bacterial Septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Haemophilus influenzae, Klebsiella pneumoniae.

Bone and Joint Infections caused by Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species.

Intra-abdominal Infections caused by E. coli, Klebsiella pneumoniae, Bacteroides fragilis, Clostridium species, Peptostreptococcus species.

Meningitis caused by Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae. Titan has also been used successfully in a limited number of cases of meningitis and shunt infection caused by Staphylococcus epidermidis and E. coli.

Surgical Prophylaxis: The preoperative administration of a single 1 gm dose of Titan may reduce the incidence of postoperative infections in patients undergoing surgical procedures classified as contaminated or potentially contaminated.

Titan is also used to associated treatment for these conditions: Arthritis gonococcal, Bacterial Endocarditis, Bacterial Infections, Bacterial Sepsis, Bacterial Sinusitis, Bone and Joint Infections, Brain abscess, Chancroid, Community Acquired Pneumonia (CAP), Conjunctivitis gonococcal neonatal, Epididymitis, Epiglottitis, Gonococcal infection of pharynx, Gonococcal pelvic inflammatory disease, Intra-Abdominal Infections, Lower respiratory tract infection bacterial, Lyme Neuroborreliosis, Meningitis, Bacterial, Ophthalmia neonatorum due to gonococcus, Postoperative Infections, Prosthetic Joint Infection, Salmonella Typhi Infection, Septic Arthritis, Shigellosis, Skin and Subcutaneous Tissue Bacterial Infections, Syphilis, Vulvovaginitis gonococcal, Whipple Disease, Bacterial otitis media, Complicated Bacterial Urinary Tract Infections, Susceptible Bacterial Infections, Uncomplicated Gonorrhea, Uncomplicated Urinary tract infection bacterial

How Titan works

Titan works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. Binding of ceftriaxone to these enzymes causes the enzyme to lose activity; therefore, the bacteria produce defective cell walls, causing cell death.

Dosage

Titan dosage

Generally, Titan should be taken once or equally devided twice a day for 4-14 days. Titan therapy should be continued for at least 2 days after the sign and symptoms of infection have disappeared.

The usual duration of therapy is 4 to 14 days; in complicated infections longer therapy may be required. No dosage adjustment is required for patients with renal or hepatic impairment.

Use the solution immediately after reconstitution of powder.

Side Effects

Generally Titan is well tolerated. However, few side effects including nausea, vomiting, diarrhea, dizziness and fever may occur.

Toxicity

Titan overdose may increase the risk of urolithiasis and subsequent post-renal acute renal failure (PARF). Other symptoms of overdose unavailable in the literature. However, they are likely similar to the adverse effects of the medication. If overdose of ceftriaxone occurs, treat with symptomatic and supportive treatment, as ceftriaxone levels will not be reduced by dialysis.

Precaution

Titan should be administered with caution to individuals with a history of gastrointestinal disease, particularly colitis.

Interaction

May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level with probenecid.

Food Interaction

No interactions found.

Volume of Distribution

The apparent volume of distribution of an intravenous or intramuscular dose in healthy patients is 5.78 to 13.5 L. The volume of distribution of an intravenous or intramuscular dose in septic patients is 6.48 to 35.2 L. Titan has good enough CSF penetration to be used as an effective treatment of bacterial meningitis.

Elimination Route

Titan is only given as an injection, either intramuscularly or intravenously. Titan is less than 1% bioavailable if given orally.

Half Life

The elimination half-life of ceftriaxone is 5.8-8.7 hours. The half-life of ceftriaxone in the middle ear fluid has been estimated to be 25 hours.

Clearance

The plasma clearance of ceftriaxone in healthy adults receiving a 0.15-3g dose is 0.58 to 1.45 L/hour. The renal clearance of ceftriaxone is 0.32 to 0.73 L/hour. In intensive care unit patients, ceftriaxone's total drug clearance was 0.96L/h (0.55-1.28 L/h), and unbound drug clearance was 1.91 L/h (1.46-6.20 L/h).

Elimination Route

Titan is primarily eliminated in the urine (33-67%). The remainder is eliminated through secretion in the bile and removed from the body via the feces.

Pregnancy & Breastfeeding use

Pregnancy: The safety of Titan in the treatment of infections during pregnancy has not been established. Titan should only be used during pregnancy if the likely benefit outweighs the potential risk to the fetus and/or the mother.

Lactation: Titan is excreted in breast milk at low concentrations. Therefore, caution should be exercised when Titan is administered to a nursing mother.

Contraindication

Titan should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics. It is contraindicated in premature infants during the first 6 weeks of life. Its safety in human pregnancy has not been established. Titan is contraindicated in neonates if they require (or are expected to require) treatment with calcium-containing IV solutions, including continuous calcium containing infusions such as parenteral nutrition because of the risk of precipitation of ceftriaxone-calcium.

Acute Overdose

There is no specific antidote. Treatment of over dosage should be symptomatic.

Storage Condition

Store below 25°C, protected from light & moisture. Use reconstituted solutions immediately.

Reconstituted solutions are stable for 6 hours at room temperature and for 24 hours at 2°-8°C. It should not be mixed in the same syringe with any drug other than 1% Lidocaine Hydrochloride injection BP (for IM injection only).

Innovators Monograph

You find simplified version here Titan

Titan contains Ceftriaxone see full prescribing information from innovator Titan Monograph, Titan MSDS, Titan FDA label

FAQ

What is Titan used for?

Titan is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.Titan is a cephalosporin antibiotic.

What are the common side effects of Titan?

Common side effects of Titan include:

  • rash,
  • diarrhea,
  • nausea,
  • vomiting,
  • upset stomach,
  • blood clots,
  • dizziness,
  • headache,
  • pain or swelling in your tongue,
  • a lump where the medicine was injected,
  • sweating,
  • vaginal itching or discharge,
  • vaginal yeast infection,
  • anemia,
  • changes in taste, or
  • flushing.

How safe is Titan?

FDA alert states that generally, fatalities have been associated with simultaneous administration of Titan and calcium-containing products.administration of the two products at different times and via different infusion lines has also been fatal.

Who should not take Titan?

A type of blood disorder where the red blood cells burst called hemolytic anemia. Liver problems. disease of the gallbladder. Severe renal impairment.

Is Titan safe during pregnancy?

At first ,Titan is not harmful for pregnant women.The U.S. Food and Drug Administration (FDA) considers Titan a pregnancy Category B medicine, which means that it has not been studied in pregnant women. However, when studied in pregnant animals, Titan showed no negative effects on unborn babies.

What are the benefits of Titan?

Titan is used to treat many kinds of bacterial infections, including severe or life-threatening forms such as E. coli, pneumonia, or meningitis.Titan is also used to prevent infection in people having certain types of surgery.

Is Titan safe during breastfeeding?

Titan is acceptable in nursing mothers.

Can I take Titan without food?

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Titan, there are no specific foods that you must exclude from your diet when receiving this medication.

Which foods should be avoided during treatment with Titan?

Foods that must be avoided while on antibiotic treatment include grapefruit, foods rich in calcium.

Can I drink alcohol after taking Titan?

It is best not to drink alcohol for up to 48 hours after the injection.

How many days should Titan injection be taken?

It is sometimes given as a single dose and sometimes given once or twice a day for 4-14 days, depending on the type of infection being treated.

How long can I take Titan?

Titan is sometimes given for up to 14 days. Read and carefully follow any Instructions for Use provided with your medicine.

Can I drive after taking Titan ?

Titan can cause dizziness. If you feel dizzy, do not drive or use any tools or machines.

How does Titan work in the body?

Titan works by interfering with the formation of bacterial cell walls. Titan impairs the bonds that hold the bacterial cell wall together, which allows holes to appear in the cell walls.

Where is Titan injected?

Titan is injected into a muscle or as an infusion into a vein (IV).

Can I take Titan without food?

In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Titan, there are no specific foods that you must exclude from your diet when receiving this medication.

*** Taking medicines without doctor's advice can cause long-term problems.
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