Tin(II) Fluoride

Tin(II) Fluoride Uses, Dosage, Side Effects, Food Interaction and all others data.

Stannous Fluoride, or Tn(II) Fluoride, is a compound commonly used in toothpastes for the prevention of gingivitis, dental infections, cavities, and to relieve dental hypersensitivity. Although similar in function and activity to Sodium Fluoride (NaF), the conventionally added ingredient in toothpastes, stannous fluoride has been shown to be more effective at stopping and reversing dental lesions . It manages and prevents dental caries and gingivitis by promoting enamel mineralization , reducing gingival inflammation and bleeding through its potential broad-spectrum antibiotic effect and modulation of the microbial composition of the dental biofilm . It is an FDA-approved over-the-counter product.

Tin(II) Fluoride mediates both bactericidal and bacteriostatic properties and provides an anti-erosive action on tooth enamel.

Trade Name Tin(II) Fluoride
Generic Stannous fluoride
Stannous fluoride Other Names difluorostannylene, fluoristan, Stannous fluoride, tin difluoride, Tin(II) fluoride
Type
Formula F2Sn
Weight Average: 156.71
Monoisotopic: 157.899002981
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Tin(II) Fluoride
Tin(II) Fluoride

Uses

Tin(II) Fluoride is a medication used to treat dental hypersensitivity, produce enamel, prevent gingivitis and cavities, and prevent periodontal infections.

Indicated for use to relieve dental hypersensitivity, increase enamel production, prevent gingivitis and cavities, and control periodontal infections.

Tin(II) Fluoride is also used to associated treatment for these conditions: Dental Cavity

How Tin(II) Fluoride works

Tin(II) Fluoride has been shown to manage and prevent dental caries and gingivitis by promoting enamel mineralization, reducing gingival inflammation and bleeding, its potential broad-spectrum antibiotic effect, and through modulation of the microbial composition of the dental biofilm. It works by depositing a stable acid-resistant layer on the tooth surfaces which is composed of calcium fluoride produced when stannous fluoride converts the calcium mineral apatite into fluorapatite. Tin and fluoride mediate anti-erosive actions by interacting with and modifying the absorbent layer composed of salivary proteins such as mucins, perhaps by enhancing the cross-linking between the proteins to result in a more resistant and protective layer against erosion . The efficacy of stannous fluoride solutions seems to depend mainly on the incorporation of tin in the mineralized dentine when the organic portion is preserved but on surface precipitation when the organic portion is continuously digested. Moreover, the relative erosion-inhibiting effects of stannous fluoride strongly depend on the presence or absence of the demineralized organic dentine matrix .

Toxicity

The oral LD50 value in rats is 360mg/kg and the dermal LD50 value is >2000mg/kg. Repeated or prolonged dermal contact can cause irritant symptoms such as reddening of the skin, blisters, or dermatitis.

Food Interaction

No interactions found.

Volume of Distribution

Tin(II) Fluoride is cleared from saliva rapidly but very well retained in gingival plaque for a prolonged period of time .

Elimination Route

Tin is retained in the demineralized organic matrix to some extent, diffuses through the phosphorylated non-collagenous proteins in the dentine called phosphophoryn and accumulates in the underlying mineralized tissue.

Half Life

The half-life for the decay of the salivary elimination rate constant was 13 min .

Clearance

Stimulated and nonstimulated salivary elimination microrate constants in this case would be ∼1 and 0.5 min^−1, respectively .

Elimination Route

Materials introduced into the oral cavity can be eliminated by salivary washout and swallowing, absorption through oral surfaces, or degradation .

Innovators Monograph

You find simplified version here Tin(II) Fluoride

*** Taking medicines without doctor's advice can cause long-term problems.
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