Tergitol NP-9

Tergitol NP-9 Uses, Dosage, Side Effects, Food Interaction and all others data.

Tergitol NP-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina during intercourse, they immobilize/inactivate/damage and/or kill sperms without eliciting systemic effects. N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and condom lubricants. It is the most commonly used spermicidal contraceptive in the UK and the USA. In several European countries, spermicides are no longer on the market.

Trade Name Tergitol NP-9
Generic Nonoxynol-9
Nonoxynol-9 Other Names Nonoxynol 9, PEG-9 nonyl phenyl ether, Tergitol NP-9
Type
Formula C33H60O10
Weight Average: 616.8235
Monoisotopic: 616.41864814
Groups Approved, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Tergitol NP-9
Tergitol NP-9

Uses

Tergitol NP-9 is a vaginal spermicide used for the non-hormonal contraception in conjunction with other modes of contraception.

Nonoxynol 9 is a surfactant spermicide used for contraception in spermicidal creams, jellies, foams, gel, and lubricants. It is also used in conjuction with other methods of contraception, including condoms, cervical caps and diaphragms.

Tergitol NP-9 is also used to associated treatment for these conditions: Contraceptive sponge therapy

How Tergitol NP-9 works

Tergitol NP-9 interacts with the lipids in the membranes of the acrosome and the midpiece of the sperm. The sperm membranes are lysed; the acrosome, neck and midpiece of the spermatozoa are loosened and then detached which results in their immobilization and death.

Toxicity

The major drawback of nonoxynol-9 is its detergent-type action on epithelial cells and the normal vaginal flora. Detergent-type spermicides alter the vaginal flora, possibly leading to an increased risk of opportunistic infections. These are known to enhance the susceptibility of the epithelium of the lower genital tract to HIV and human papillomavirus infection. N-9 can cause vaginal irritation and allergic vaginitis as well as genital irritation in male partners.

Food Interaction

No interactions found.

Innovators Monograph

You find simplified version here Tergitol NP-9

*** Taking medicines without doctor's advice can cause long-term problems.
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