Tenoxicamum Uses, Dosage, Side Effects, Food Interaction and all others data.

Tenoxicamum is a non-steroidal antiinflammatory drug (NSAID) with anti inflammatory, analgesic, antipyretic properties and it also inhibits platelet aggregation. Tenoxicamum inhibits prostaglandin biosynthesis and used in the treatment of inflammatory and degenerative disorders of the musculoskeletal system.

Tenoxicamum, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.

Trade Name Tenoxicamum
Generic Tenoxicam
Tenoxicam Other Names Tenoxicam, Ténoxicam, Tenoxicamum
Formula C13H11N3O4S2
Weight Average: 337.37
Monoisotopic: 337.019098194
Protein binding


Groups Approved
Therapeutic Class Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Available Country
Last Updated: September 19, 2023 at 7:00 am


Tenoxicamum is used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout, and extra-articular inflammations such as tendinitis, bursitis and periarthritis of the shoulders or hips. It is also used for musculoskeletal & postoperative pain and in primary dysmenorrhea.

Tenoxicamum is also used to associated treatment for these conditions: Backache, Osteoarthritis (OA), Pain, Rheumatoid Arthritis

How Tenoxicamum works

The antiinflammatory effects of tenoxicam may result from the inhibition of the enzyme cycooxygenase and the subsequent peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, their inhibition accounts for the peripheral analgesic effects of tenoxicam. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.


Tenoxicamum dosage

For all indications (except primary dysmenorrhea, post-operative pain and acute gout) the usual recommended dose is 20 mg once daily. Tenoxicamum should be taken at the same time of day; in case of rheumatoid arthritis Tenoxicamum should be taken at night to relieve the morning stiffness. The recommended dose for primary dysmenorrhea is 20 to 40 mg once daily. For post-operative pain the recommended dose is 40 mg once daily up to five days and for acute attacks of gout the recommended dose is 40 mg once daily for two days followed by 20 mg once daily for a further five days.

Tenoxicamum is not recommended for use in patients under 16 years of age.

Side Effects

Tenoxicamum is well tolerated in the recommended doses. The usual side effects are mild and transient gastric, abdominal discomfort, dyspepsia, heartburn, nausea, dizziness, headache, itching, erythema, rash, urticaria, increase in BUN or creatinine, edema and palpitations. In isolated cases GI-perforation, asthma, angioedema and elevated blood pressure may occur.


Caution should be exercised in patients have symptoms of gastrointestinal diseases. If peptic ulceration or gastrointestinal bleeding occurs, Tenoxicamum should be immediately withdrawn. It is necessary to adequately monitor the patient with increased risk of developing renal failure, impaired renal function in diabetics, hepatic cirrhosis and congestive heart failure. Patients having coagulation disorders or receiving therapy that interferes with haemostasis should, however, be carefully observed when treated with Tenoxicamum. In women who have difficulty conceiving or are undergoing investigation of infertility, withdrawal of Tenoxicamum should be considered.


Salicylates increase the clearance and volume of distribution of Tenoxicamum by displacing it from protein binding sites. Concurrent treatment with salicylate or other NSAIDs is not recommended because of increased risk of undesirable reactions. Co-administration of Tenoxicamum and methotrexate has been associated with reduced renal tubular secretion of methotrexate. As with NSAIDs in general, Tenoxicamum should not be administered concurrently with potassium sparing diuretics. Tenoxicamum might attenuate the antihypertensive effects of adrenergic blockers and ACE-inhibitors. It may also enhance the effect of antidiabetic drug (sulphonylurea group).

Food Interaction

  • Take with food. Food may minimize stomach upset caused by tenoxicam.

Elimination Route

Oral absorption of tenoxicam is rapid and complete (absolute bioavailability 100%).

Half Life

72 hours (range 59 to 74 hours)

Pregnancy & Breastfeeding use

The safety of Tenoxicamum during pregancy has not been established therefore it should be used with caution during pregnancy and only if the benefit to the mother is greater than the risk of the fetus. There is no information available about the safety of Tenoxicamum during breastfeeding therefore it should not be used during lactation.


Tenoxicamum should not be administered to patients with active peptic ulcer or active inflammatory diseases of the gastrointestinal tract. Tenoxicamum is contraindicated in patients who have shown hypersensitivity to the drug. It should not be used in patients in whom acute asthmatic attacks, urticaria, rhinitis or other allergic manifestations are precipitated by ASA or other nonsteroidal anti-inflammatory agents. Fatal anaphylactoid reactions have occurred in such individuals. Before anesthesia or surgery, Tenoxicamum should not be given to elderly patients, to patients at risk of renal failure, or to patients with increased risk of bleeding, because of an increased risk of acute renal failure and possibility of impaired hemostasis. Tenoxicamum is relatively contraindicated in patients with liver dysfunction.

Acute Overdose

Although there is no experience of acute overdosage with Tenoxicamum. Overdose should be countered by reducing absorption (eg. gastrolavage and charcoal) and speed up elimination (eg. cholestyramine).

Storage Condition

Store in cool and dry place, away from children.

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What is Tenoxicamum used for?

Tenoxicamum is used to reduce pain, swelling, joint stiffness, and other symptoms from rheumatoid arthritis, osteoarthritis, and other inflammatory conditions.

What are the common side effects of Tenoxicamum?

The common side effects of Tenoxicamum are include:

Upset stomach, nausea, heartburn, dizziness, drowsiness, diarrhea, and headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. This medication may raise your blood pressure.

How do I take Tenoxicamum?

Take one tablet a day, preferably after a meal or snack.

Is Tenoxicamum safe during pregnancy?

Tenoxicamum can be taken in the first and second trimester when necessary, but it is a contraindication in the third trimester.

Is Tenoxicamum safe during breastfeeding?

This medication passes into breast milk. If you are a breast-feeding mother and are taking Tenoxicamum, it may affect your baby.

Can I drink alcohol with Tenoxicamum?

This medicine may cause stomach bleeding. Daily use of alcohol may increase your risk for stomach bleeding.

Can I take Tenoxicamum long time?

Take this medication at the lowest effective dose for the shortest possible time. Do not increase your Tenoxicamum, take it more frequently, or take it for a longer time than prescribed.

How does Tenoxicamum work??

Tenoxicamum works by blocking the effect of chemicals in your body, called cyclo-oxygenase enzymes.

Will Tenoxicamum affect my fertility?

Tenoxicamum may affect egg release (ovulation). This may affect being able to get pregnant. This goes back to normal when this drug is stopped.

Can I drive after taking Tenoxicamum?

Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you. Have your blood work checked if you are on this drug for a long time.

What is the effect of Tenoxicamum on the Kidneys?

Consumption of Tenoxicamum can harm for kidneys. So it is important to take medical advice beforehand.

What is the effect of Tenoxicamum on the Liver?

There may be severe side effects of Tenoxicamum on your liver. Do not take it unless a doctor says.

What is the effect of Tenoxicamum on the Heart?

The heart can be affected by Tenoxicamum. If you experience any unwanted effects of this drug, stop taking it and consult your doctor. You should restart the medicine only after medical advice.

Is Tenoxicamum able to treat mental disorders?

No, Tenoxicamum cannot treat any kind of mental disorder.

*** Taking medicines without doctor's advice can cause long-term problems.