Tamsunax Uses, Dosage, Side Effects, Food Interaction and all others data.

Tamsunax is an antagonist of α1A-adrenoreceptors in the prostate. It binds selectively and competitively to postsynaptic α1A-adrenoreceptors, which convey smooth muscle contraction, thereby relaxing prostatic and urethral smooth muscle.

Tamsunax is an alpha adrenoceptor blocker with specificity for the alpha-1A and alpha-1D subtypes, which are more common in the prostate and submaxillary tissue. The final subtype, alpha-1B, are most common in the aorta and spleen. Tamsunax binds to alpha-1A receptors 3.9-38 times more selectively than alpha-1B and 3-20 times more selectively than alpha-1D. This selectivity allows for a significant effect on urinary flow with a reduced incidence of adverse reactions like orthostatic hypotension.

Trade Name Tamsunax
Availability Prescription only
Generic Tamsulosin
Tamsulosin Other Names Tamsulosin, Tamsulosina, Tamsulosine, Tamsulosinum
Related Drugs finasteride, Flomax, prazosin, tadalafil, doxazosin, Cialis
Formula C20H28N2O5S
Weight Average: 408.512
Monoisotopic: 408.171892706
Protein binding

Tamsulosin is 94%-99% protein bound, mostly to alpha-1-acid glycoprotein.

Groups Approved, Investigational
Therapeutic Class BPH/ Urinary retention/ Urinary incontinence
Available Country Switzerland
Last Updated: September 19, 2023 at 7:00 am


Tamsunax Hydrochloride is used for the treatment of the signs and symptoms of Benign Prostatic Hyperplasia (BPH).

Tamsunax is also used to associated treatment for these conditions: Benign Prostatic Hyperplasia (BPH), Benign Prostatic Hypertrophy, Bladder Outlet Obstruction, Ureteral Calculus

How Tamsunax works

Tamsunax is a blocker of alpha-1A and alpha-1D adrenoceptors. About 70% of the alpha-1 adrenoceptors in the prostate are of the alpha-1A subtype. By blocking these adrenoceptors, smooth muscle in the prostate is relaxed and urinary flow is improved. The blocking of alpha-1D adrenoceptors relaxes the detrusor muscles of the bladder which prevents storage symptoms. The specificity of tamsulosin focuses the effects to the target area while minimizing effects in other areas.


Tamsunax dosage

The recommended dose of Tamsunaxis 0.4 mg once daily. It should be administered approximately half/hour following the same meal each day. For those patients who fail to respond to the 0.4 mg dose after two to four weeks of dosing, the dose of Tamsunax can be increased to 0.8mg once daily. If Tamsunax administration is discontinued or interrupted for several days at either the 0.4 mg or 0.8 mg dose, therapy should be started again with the 0.4 mg once daily dose.

Side Effects

The following adverse reactions have been reported during the use of Tamsunax: dizziness, abnormal ejaculation, and less frequently (1-2%) headache, asthenia, postural hypotension, palpitations, and rhinitis.

Gastrointestinal reactions such as nausea, vomiting, diarrhoea, and constipation can occasionally occur. Hypersensitivity reactions such as rash, pruritus, and urticaria can occur occasionally. As with other alpha-blockers, drowsiness, blurred vision, dry mouth, or edema can occur. Syncope has been reported rarely, and there have been very rare reports of angioedema and priapism.


In the event of overdose, patients may experience hypotension and should lie down in a supine position to maintain blood pressure and heart rate. If further measures are required intravenous fluids should be considered. If further progression is required, vasopressors may be used and renal function should be monitored. Dialysis is unlikely to assist in treating overdose because tamsulosin is extensively protein bound.

The oral LD50 in rats is 650mg/kg.

Tamsunax is not indicated for use in women and no studies have been performed in pregnancy, though animal studies have not shown fetal harm. Tamsunax is excreted in the milk of rats but there is no available data on what the effect of this tamsulosin exposure may be. Animal studies have shown male and female rat fertility is affected by tamsulosin due to impairment of ejaculation and fertilization. In men, tamsulosin is associated with abnormal ejaculation. Tamsunax is not mutagenic but may be carcinogenic at levels above the maximum recommended human dose. Female rats experience a slight increase in the rates of mammary gland fibroadenomas and adenocarcinomas.


Not indicated for use in women. Severe renal impairment (CrCl <10 mL/min). Pregnancy and lactation.


Increased plasma concentration with strong CYP3A4 inhibitors (e.g. ketoconazole). Moderate CYP3A4 inhibitors (e.g. erythromycin), strong (e.g. paroxetine) or moderate (e.g. terbinafine) CYP2D6 inhibitors may increase exposure of tamsulosin. Increased plasma concentration with cimetidine. Additive effect with other α-adrenergic blocking agents. Concomitant use with PDE5 inhibitors may lead to symptomatic hypotension. Decreased plasma concentration with furosemide.

Food Interaction

  • Take after a meal. Take 30 minutes after the same meal each day to reduce plasma level variations.

[Moderate] ADJUST DOSING INTERVAL: Food may delay the gastrointestinal absorption of tamsulosin.

The time to maximum plasma concentration (Tmax) is reached by 4 to 5 hours under fasted conditions and by 6 to 7 hours when tamsulosin is administered with food.

The delay in Tmax has the desirable effect of smoothing the tamsulosin plasma concentration profile, thereby reducing fluctuation of the plasma peak and trough concentrations with multiple dosing.

Food may also affect the extent of absorption of tamsulosin.

It has been reported that taking tamsulosin under fasted conditions results in a 30% increase in bioavailability (AUC) and 40% to 70% increase in peak plasma concentration (Cmax) compared to fed conditions.

The effects of food on the pharmacokinetics of tamsulosin are consistent regardless of whether tamsulosin is taken with a light meal or a high-fat meal.

MANAGEMENT: To ensure uniformity of absorption, tamsulosin should be administered approximately one-half hour following the same meal each day.

Tamsunax Alcohol interaction


The concurrent use of ethanol and alpha-1 adrenergic blockers may cause increased hypotensive effects.

Patients with aldehyde dehydrogenase deficiencies (primarily Asians) may be at a higher risk of this interaction.

The mechanism has not been determined.

Data exist for prazosin and other alpha adrenergic blockers are expected to interact also.

In addition, any patients taking alpha adrenergic blockers may experience excessive orthostatic hypotension with ethanol ingestion, due to ethanol's unopposed vasodilatory effects in the presence of alpha adrenergic blockade.

Patients who develop

a flushing reaction after ethanol ingestion (indicates a possible aldehyde dehydrogenase deficiency) should be advised to avoid ethanol or limit their intake.

All patients should be warned about the possibility of orthostatic hypotension with concurrent ethanol use.

Volume of Distribution

16L after intravenous administration.

Elimination Route

Oral tamsulosin is 90% absorbed in fasted patients. The area under the curve is 151-199ng/mL*hr for a 0.4mg oral dose and 440-557ng/mL*hr for a 0.8mg oral dose. The maximum plasma concentration is 3.1-5.3ng/mL for a 0.4mg oral dose and 2.5-3.6ng/mL for a 0.8mg oral dose. Taking tamsulosin with food increases the time to maximum concentration from 4-5 hours to 6-7 hours but increases bioavailability by 30% and maximum plasma concentration by 40-70%.

Half Life

The half life in fasted patients is 14.9±3.9 hours. The elimination half life is 5-7 hours and the apparent half life is 9 to 13 hours in healthy subjects. In patients who require tamsulosin, the apparent half life is 14-15 hours.



Elimination Route

97% of an orally administered does is recovered in studies, which 76% in the urine and 21% in the feces after 168 hours. 8.7% of the dose is excreted as unmetabolized tamsulosin.

Pregnancy & Breastfeeding use

Tamsunax Hydrochloride capsules are not indicated for use in women.


History of orthostatic hypotension. Severe hepatic impairment.

Special Warning

Tamsunax Hydrochloride capsules are not indicated for use in pediatric populations.

Acute Overdose

As overdose of Tamsunax Hydrochloride capsules lead to hypotension, support the cardiovascular system is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in supine position. If this measure is inadequate, then administration of intravenous fuid should be considered. Measures, such as emesis, can be taken to impede absorption. When large quantities are involved, gastric lavage can be applied and activated charcoal and an osmotic laxative, such as sodium sulphate, can be administered.

Storage Condition

Store between 20-25° C.

Innovators Monograph

You find simplified version here Tamsunax

Tamsunax contains Tamsulosin see full prescribing information from innovator Tamsunax Monograph, Tamsunax MSDS, Tamsunax FDA label


What is Tamsunax used for?

Tamsunax used to treat men with symptoms of an enlarged prostate . It's also occasionally taken to treat kidney stones.Tamsunax helps reduce the symptoms of an enlarged prostate gland by relaxing the muscles in the bladder and prostate so you can pee more easily.

How safe is Tamsunax?

Long-term treatment with Tamsunax is safe and well tolerated in patients with lower urinary tract symptoms/benign prostatic hyperplasia.

What are the common side effects of Tamsunax?

Dizziness, lightheadedness, drowsiness, runny/stuffy nose, or ejaculation problems may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Can I take Tamsunax while pregnant?

Tamsunax is not for use by women. This medicine can cause birth defects if a woman is exposed to it during pregnancy.Tamsunax capsules should not be handled by a woman who is pregnant or who may become pregnant.

Is Tamsunax safe during breastfeeding?

If you take Tamsunax while breastfeeding there's a risk of the Tamsunax getting into your breast milk. This may mean your baby gets some side effects from the medicine.

How quickly does Tamsunax work?

Tamsunax are reached within four to five hours when a Tamsunax capsule is taken on an empty stomach, or within six to seven hours when Tamsunax is taken with food.

Can Tamsunax affect memory?

Recently shown that men taking Tamsunax have a higher risk of developing dementia when compared to men taking other α-adrenergic antagonists or no α-adrenergic antagonists at all.

Is Tamsunax safe for long term use?

Long-term treatment with Tamsunax is safe and well tolerated in patients with lower urinary tract symptoms/benign prostatic hyperplasia.

Does Tamsunax affect sleep?

Tamsunax improves nocturia and sleep disturbances by increasing the number of hours of undisturbed sleep

Does Tamsunax make me pee more?

Tamsunax helps relax the muscles in the prostate and the opening of the bladder. This may help increase the flow of urine or decrease the symptoms.

Does Tamsunax break kidney stones?

Tamsunax can boost the passage of large kidney stones, but not small ones.

Can I drink alcohol with Tamsunax?

It's usually safe to drink alcohol with Tamsunax. However, during the first few days of taking Tamsunax, It's best not to drink alcohol. Alcohol can increase the blood pressure-lowering effect and this can make you feel dizzy or lightheaded.

Can I drive after taking Tamsunax?

Tamsunax can make some people feel dizzy or lightheaded, especially when they first start taking it. If this happens to you, do not drive a car, ride a bike, or use tools or machinery.

How long should a man take Tamsunax?

The low incidence of acute urinary retention in patients treated with Tamsunax for up to 6 years suggests that Tamsunax may reduce the risk of AUR in patients with BPH.

When is the best time to take Tamsunax?

Tamsunax will be taken approximately one half hour following the same meal each day.

When should I stop taking Tamsunax?

For kidney stones – your doctor may tell you to stop taking it if your stones have gone or if the medicine is not helping you.

*** Taking medicines without doctor's advice can cause long-term problems.